Mouse anti-Human MMP2 Monoclonal Antibody | anti-MMP2 antibody

MMP2 antibody

Cat. Num. AAA531641

• Gene Names: Mmp2; 2-MMP; anon-WO0118547.84; CG1794; dm-2MMP; Dm2-MMP; DmelCG1794; dmmp2; l(2)02353; mmp2; MMP2
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Synonyms: MMP2; Monoclonal Antibody; MMP2 antibody; Monoclonal MMP2; Anti-MMP2; MMP-2; MMP 2; Matrix Metalloproteinase 2; anti-MMP2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1κ
• Clone Number: 42-5D11
• Specificity: Human
• Form/Format: Purified immunoglobuling supplied in 0.1M Sodium Phosphate Buffer, pH 7.0, containing 2% protease-free BSA.
• Concentration: 2.0mg/ml (varies by lot)

• Applicable Applications for anti-MMP2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western Blot: 1-5 ug/ml; Immunohistochemistry - Frozen: 0.9 ug/ml; Immunohistochemistry - Paraffin: 1-5 ug/ml (using PLP fixation)
• Cross-Reactivity: Bovine, horse, rabbit, rat, mouse, pig
• Immunogen: Synthetic oligopeptide corresponding to amino acid residue 468-483 of human matrix metalloproteinase 2
• Epitope: Amino acids 468-483 (VTPRDKPMGPLLVATF)
• Preparation and Storage: Ships on blue ice. Upon receipt, store at -20°C.

Western Blot (WB)

(MMP2 recombinant protein lysate was probed with MMP2 antibody (1:1000 dilution). Arrow indicates target (~74 kDa).)

Related Product Information for anti-MMP2 antibody

72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakDaown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.

Product Categories/Family for anti-MMP2 antibody

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 45552531
• NCBI GeneID: 35997
• NCBI Accession #: NP_995788.1
• NCBI GenBank Nucleotide #: NM_206066.2
• UniProt Accession #: Q8MPP3
• NCBI Official Full Name: matrix metalloproteinase 2, isoform B
• NCBI Official Synonym Full Names: Matrix metalloproteinase 2
• NCBI Official Symbol: Mmp2
• NCBI Official Synonym Symbols: 2-MMP; anon-WO0118547.84; CG1794; dm-2MMP; Dm2-MMP; DmelCG1794; dmmp2; l(2)02353; mmp2; MMP2
• NCBI Protein Information: CG1794 gene product from transcript CG1794-RB
• UniProt Protein Name: FI21212p1
• Protein Family: Matrix metalloproteinase
• UniProt Gene Name: Mmp2
• UniProt Entry Name: Q8MPP3_DROME

Uniprot Description

Has metalloproteinase activity (PubMed:11967260). Required for larval tissue histolysis during metamorphosis and is involved in pupal head eversion and fusion of the wing imaginal tissue (PubMed:12530966). Required for growth of the dorsal air sac primordium and development of the dorsal air sacs (PubMed:19751719). Promotes embryonic motor axon fasciculation (PubMed:18045838). Cleaves and activates frac to promote motor axon bundling during outgrowth (PubMed:21471368). Promotes the reshaping of adult sensory neuron dendrites from a radial to lattice-like shape which occurs after eclosion by degrading the basement membrane on which the dendrites grow (PubMed:20412776). Involved in inhibition of follicle stem cell proliferation by cleaving Dlp, inhibiting its interaction with wg and preventing Dlp-mediated spreading of wg to follicle stem cells to enhance their proliferation (PubMed:25267296). Plays a role in wound healing (PubMed:22262460). Involved in fat body dissociation which occurs during metamorphosis by degrading basement membrane components, leading to destruction of cell-basement membrane junctions (PubMed:25520167). Required for posterior follicle cell degradation and ovulation (PubMed:25695427).