Rabbit Cytoglobin Polyclonal Antibody | anti-CYGB antibody

Cytoglobin Antibody

Cat. Num. AAA5312953

• Gene Names: CYGB; HGB; STAP
• Applications: Western Blot
• Purity: Affinity Chromatography
• Synonyms: Cytoglobin; Polyclonal Antibody; Cytoglobin Antibody; Affinity Purified Rabbit Polyclonal Cytoglobin Antibody; Polyclonal Cytoglobin antibody; Anti-Cytoglobin antibody; CYGB antibody; HGB antibody; STAP antibody; anti-CYGB antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Chromatography
• Form/Format: Lyophilized Form
• Sequence Length: 190

• Applicable Applications for anti-CYGB antibody: Western Blot (WB)
• Immunogen: Cytoglobin antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human Cytoglobin, identical to the related rat sequence, different from the related Rabbit sequence by one amino acid, as the immunogen
• Preparation and Storage: Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Lane 1:Rat Brain Tissue Lysate; Lane 2:Rat Small Intestin Tissue Lysate; Lane 3:Rat Liver Tissue Lysate; Lane 4:Rat kidney Tissue Lysate; Lane 5:SGC cell Lysate; Lane 6:COLO320 cell Lysate; Lane 7:SMMC cell Lysate; Lane 8:PANC cell Lysate; Lane 9:HELA cell Lysate)

Related Product Information for anti-CYGB antibody

Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress. The cytoglobin gene is mapped on 17q25.1. The CYGB gene contains 4 exons and spans about 9 kb. Cytoglobin has many elements common to vertebrate globins, including invariant histidine residues, and the amino acids that form the heme pocket share similarity with pentacoordinate myoglobin. In contrast to the high oxygen affinities displayed by most hexacoordinate hemoglobins, the characteristics of CYGB indicate that it can facilitate oxygen transport. Because the oxygen affinity of CYGB is more similar to myoglobin than to neuroglobin, and the oxy form of CYGB resists autooxidation.

Product Categories/Family for anti-CYGB antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 19549331
• NCBI GeneID: 114757
• NCBI GenBank Nucleotide #: NP_599030.1
• UniProt Accession #: Q8WWM9
• NCBI Official Full Name: cytoglobin
• NCBI Official Synonym Full Names: cytoglobin
• NCBI Official Symbol: CYGB
• NCBI Official Synonym Symbols: HGB; STAP
• NCBI Protein Information: cytoglobin
• UniProt Protein Name: Cytoglobin
• Protein Family: Cytoglobin
• UniProt Gene Name: CYGB
• UniProt Synonym Gene Names: STAP; HGb
• UniProt Entry Name: CYGB_HUMAN

NCBI Description

This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

Uniprot Description

CYGB: May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Belongs to the globin family.

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: neuron projection; cell soma; cytoplasm

Molecular Function: peroxidase activity; iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: oxygen transport; response to oxidative stress