Rabbit Hsp105 Polyclonal Antibody | anti-Hsp105 antibody

Hsp105 Antibody

Cat. Num. AAA5312912

• Gene Names: HSPH1; HSP105; HSP105A; HSP105B; NY-CO-25
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Chromatography
• Synonyms: Hsp105; Polyclonal Antibody; Hsp105 Antibody; Affinity Purified Rabbit Polyclonal Hsp105 Antibody; Polyclonal Hsp105 antibody; Anti-Hsp105 antibody; Hsp-105; Hsp 105 antibody; Hsp-105 antibody; Hsp 105; anti-Hsp105 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Chromatography
• Form/Format: Lyophilized Form
• Sequence Length: 858

• Applicable Applications for anti-Hsp105 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Immunogen: Hsp105 antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human HSP105, different from the related Rabbit sequence by one amino acid, and different from the related rat sequence by two amino acids, as the immunogen
• Preparation and Storage: Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded section of Rat Intestines Tissue)

Western Blot (WB)

(Lane 1: Rat Ovary Tissue Lysate; Lane 2: A549 Cell Lysate; Lane 3: U87 Cell Lysate; Lane 4: Hela Cell Lysate)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded section of Human Mammary Cancer Tissue)

Related Product Information for anti-Hsp105 antibody

Heat shock proteins (HSPs) are ubiquitously expressed in all organisms. The Hsps fall into five general families: Hsp105, Hsp90, Hsp70, the low molecular weight Hsps, and the immunophilins. The Hsp105 (also called Hsp110) family is composed of Hsp105, Apg 1 and Apg 2. The Hsp90 family consists of Hsp90, Hsp90 and GRP94. The Hsp70 family is comprised of Hsp70, HSC70, GRP78 and GRP75. The low molecular weight Hsps includes Hsp10, Hsp25, Hsp27 and Hsp32. Hsp56 and FKBP12 are immunophilins and bind to immunosuppressive drugs.

Product Categories/Family for anti-Hsp105 antibody

Protein Modification & Stress Response

NCBI and Uniprot Product Information

• NCBI GI #: 42544159
• NCBI GeneID: 10808
• NCBI GenBank Nucleotide #: NP_006635.2
• UniProt Accession #: Q92598
• NCBI Official Full Name: heat shock protein 105 kDa isoform 1
• NCBI Official Synonym Full Names: heat shock protein family H (Hsp110) member 1
• NCBI Official Symbol: HSPH1
• NCBI Official Synonym Symbols: HSP105; HSP105A; HSP105B; NY-CO-25
• NCBI Protein Information: heat shock protein 105 kDa
• UniProt Protein Name: Heat shock protein 105 kDa
• UniProt Gene Name: HSPH1
• UniProt Synonym Gene Names: HSP105; HSP110; KIAA0201
• UniProt Entry Name: HS105_HUMAN

NCBI Description

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

Uniprot Description

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein