<
Western Blot (WB)
(Anti-Hsp105 antibody, MBS175739, Western blottingLane 1: Rat Ovary Tissue LysateLane 2: A549 Cell LysateLane 3: U87 Cell LysateLane 4: HELA Cell Lysate )
Rabbit Hsp105 Polyclonal Antibody | anti-HSPH1 antibody
Anti-Hsp105 antibody
Gene Names
HSPH1; HSP105; HSP105A; HSP105B; NY-CO-25
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunohistochemistry
Purity
Immunogen affinity purified.
Synonyms
Hsp105; Polyclonal Antibody; Anti-Hsp105 antibody; Heat shock protein 105 kDa; heat shock 105kDa/110kDa protein 1; Antigen NY CO 25 antibody; Antigen NY-CO-25 antibody; DKFZp686M05240 antibody; Heat shock 105kD alpha antibody; Heat shock 105kD antibody; Heat shock 105kD beta antibody; Heat shock 105kDa protein 1 antibody; Heat shock 105kDa protein antibody; Heat shock 105kDa/110kDa protein 1 antibody; Heat shock 110 kDa protein antibody; Heat shock 110kDa protein antibody; Heat shock protein 105 kDa antibody; HS105_HUMAN antibody; HSP105 antibody; HSP105A antibody; HSP105B antibody; HSP110 antibody; HSPH 1 antibody; HSPH1 antibody; KIAA0201 antibody; NY CO 25 antibody; anti-HSPH1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
858
Applicable Applications for anti-HSPH1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Hsp105 (713-733aa EVMEWMNNVMNAQAKKSLDQD), different from the related mouse sequence by one amino acid, and different from the related rat sequence by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti-Hsp105 antibody, MBS175739, Western blottingLane 1: Rat Ovary Tissue LysateLane 2: A549 Cell LysateLane 3: U87 Cell LysateLane 4: HELA Cell Lysate )
Western Blot (WB)
(Anti-Hsp105 antibody, MBS175739, Western blottingLane 1: Rat Ovary Tissue LysateLane 2: A549 Cell LysateLane 3: U87 Cell LysateLane 4: HELA Cell Lysate )
Immunohistochemistry (IHC)
(Anti-Hsp105 antibody, MBS175739, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Hsp105 antibody, MBS175739, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Hsp105 antibody, MBS175739, IHC(P)IHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-Hsp105 antibody, MBS175739, IHC(P)IHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-Hsp105 antibody, MBS175739, IHC(F)IHC(F): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-Hsp105 antibody, MBS175739, IHC(F)IHC(F): Rat Intestine Tissue )
Related Product Information for anti-HSPH1 antibody
Description: Rabbit IgG polyclonal antibody for Heat shock protein 105 kDa(HSPH1) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.
Background: HSP105(HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene. Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm. Database analysis indicates that both HSP105 isoforms are highly conserved during evolution. By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13. Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock. HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses. Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position. Besides, HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer.
Background: HSP105(HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene. Immunohistochemical analysis localizes HSP105 mainly in the cytoplasm. Database analysis indicates that both HSP105 isoforms are highly conserved during evolution. By analysis of radiation hybrids and human/rodent hybrid cell lines, the HSPH1 gene is mapped to chromosome 13. Both HSP105-alpha and HSP105-beta are upregulated in HeLa cells exposed to heat shock. HSP105-alpha, but not HSP105-beta, is also upregulate in response to other cell stresses. Following heat shock, HSP105 relocalizes from a cytoplasmic to perinuclear position. Besides, HSP110 may thus constitute a major determinant for both prognosis and treatment response in colorectal cancer.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
97,460 Da
NCBI Official Full Name
Heat shock protein 105 kDa
NCBI Official Synonym Full Names
heat shock 105kDa/110kDa protein 1
NCBI Official Symbol
HSPH1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; NY-CO-25
NCBI Protein Information
heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha
UniProt Protein Name
Heat shock protein 105 kDa
Protein Family
UniProt Gene Name
HSPH1
UniProt Synonym Gene Names
HSP105; HSP110; KIAA0201
UniProt Entry Name
HS105_HUMAN
Uniprot Description
HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.
Protein type: Heat shock protein; Chaperone
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol
Molecular Function: protein binding; ATP binding; alpha-tubulin binding
Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein
Research Articles on HSPH1
Similar Products
Product Notes
The HSPH1 hsph1 (Catalog #AAA175739) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hsp105 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Hsp105 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin. Researchers should empirically determine the suitability of the HSPH1 hsph1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hsp105, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
