SDS-PAGE
AATK recombinant protein
AATK recombinant protein
SDS-PAGE
SDS-PAGE
Scientific Background: AATK or apoptosis-associated tyrosine kinase contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. AATK is induced during apoptosis, and expression of this protein is a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells (1). AATK is highly detected in brain, lung, kidney, and pancreas (2). AATK is also shown to produce neuronal differentiation in a neuroblastoma cell line.
2. Ishikawa, K. et.al: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998.
NCBI and Uniprot Product Information
Uniprot Description
Function: May be involved in neuronal differentiation
By similarity.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subunit structure: Interacts with CDK5
By similarity.
Subcellular location: Membrane; Single-pass type I membrane protein Ref.3. Cytoplasm. Cytoplasm › perinuclear region
By similarity. Cell projection › dendrite. Cell projection › axon. Cell projection › growth cone. Note: Predominantly perinuclear
By similarity. Ref.3Isoform 2: Membrane. Note: Peripheral membrane protein. Ref.3Isoform 3: Membrane; Single-pass type I membrane protein Ref.3.
Tissue specificity: Expressed in brain, and, to a lower extent, in kidney, heart, lung and skeletal muscle. In the brain, expressed in the olfactory bulb, cerebellum, striatum, hippocampal formation, thalamus, hypothalamus, and pontine nuclei (at protein level). Ref.1 Ref.2 Ref.3 Ref.8
Developmental stage: Isoform 2 is predominantly expressed in adult stage. Isoform 3 is up-regulated during postnatal development. Ref.3
Induction: Up-regulated during the apoptotic death of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Ref.1 Ref.2
Post-translational modification: Autophosphorylated. Phosphorylated by CDK5
By similarity. Ref.3 Ref.8
Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.Contains 1 protein kinase domain.
Sequence caution: The sequence BAC41437.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on AATK
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Product Notes
The AATK aatk (Catalog #AAA515382) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 8-411 with tag GST tag!!Expression System||Sf9 insect cells using baculovirus!!Source Note||Recombinant mouse AATK (8-411) was expressed by baculovirus in Sf9 insect cells. AAA Biotech's AATK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the AATK aatk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AATK, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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