Western Blot (WB)
(Western blot detection of IMP3 in MCF7, SKVO3, NTERA2, Jurkat, Hela and K562 cell lysates using IMP3 mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.)
anti-Human IMP3 Monoclonal Antibody | anti-IMP3 antibody
Anti-IMP3 Mouse mAb
Source: Human
Western Blot (WB)
(Western blot detection of IMP3 in MCF7, SKVO3, NTERA2, Jurkat, Hela and K562 cell lysates using IMP3 mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.)
Western Blot (WB)
(Western blot detection of IMP3 in MCF7, SKVO3, NTERA2, Jurkat, Hela and K562 cell lysates using IMP3 mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa.)
UniPort Summary Function: RNA-binding protein that act as a regulator of mRNA translation and stability.Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.Binds to sequences in the 3'-UTR of CD44 mRNA.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
Uniprot Description
IGF2BP3: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA. Belongs to the RRM IMP/VICKZ family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Spliceosome; Translation
Chromosomal Location of Human Ortholog: 7p15.3
Cellular Component: cytoplasm; cytosol
Molecular Function: mRNA 3'-UTR binding; mRNA 5'-UTR binding; protein binding; RNA binding; translation regulator activity
Biological Process: anatomical structure morphogenesis; gene expression; negative regulation of translation; regulation of cytokine biosynthetic process; translation
Research Articles on IMP3
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Product Notes
The IMP3 igf2bp3 (Catalog #AAA475125) is an Antibody produced from Mouse Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti-IMP3 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IMP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the IMP3 igf2bp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IMP3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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