Rabbit anti-Mouse, Human IGF2BP3 Polyclonal Antibody | anti-IGF2BP3 antibody

Anti-IGF2BP3 Antibody

Cat. Num. AAA847757

• Gene Names: IGF2BP3; CT98; IMP3; KOC1; IMP-3; VICKZ3
• Reactivity: Mouse, Human
• Applications: Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Purity: Affinity purification
• Synonyms: IGF2BP3; Polyclonal Antibody; Anti-IGF2BP3 Antibody; CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3; insulin-like growth factor 2 mRNA-binding protein 3; anti-IGF2BP3 antibody

• Host: Rabbit
• Reactivity: Mouse, Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Affinity purified rabbit polyclonal antibody to IGF2BP3
• Purity/Purification: Affinity purification
• Form/Format: Liquid. In PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Applicable Applications for anti-IGF2BP3 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: IHC 1:50-1:200; IF: 1:50-1:200; WB: 1:500-1:2000; IP: 1:20-1:50
• Immunogen: Recombinant fusion protein corresponding to aa300-579 of human IGF2BP3
• Preparation and Storage: Store at -20 degree C; The antibody solution should be gently mixed before use.; Shelf life: ~12 months

Immunocytochemistry/Immunofluorescence (ICC/IF))

Immunohistochemistry (IHC)

Western Blot (WB)

Western Blot (WB)

Related Product Information for anti-IGF2BP3 antibody

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.

Product Categories/Family for anti-IGF2BP3 antibody

Primary Antibodies; Cancer Research; Tumor Biomarkers; Antibodies; Antibodies & Supporting Tools; Antibodies for Metabolic Processes; Primary Antibodies (A-Z); Diabetes; Obesity & Metabolic Syndrome; Antibodies for Epigenetics Research; Epigenetics; Epige

NCBI and Uniprot Product Information

• NCBI GI #: 30795212
• NCBI GeneID: 10643
• NCBI Accession #: NP_006538.2
• NCBI GenBank Nucleotide #: NM_006547.2
• UniProt Accession #: O00425; Q63HM0; Q6MZZ2; Q86VB1; A0A4Z5
• Molecular Weight: 63,705 Da
• NCBI Official Full Name: insulin-like growth factor 2 mRNA-binding protein 3
• NCBI Official Synonym Full Names: insulin-like growth factor 2 mRNA binding protein 3
• NCBI Official Symbol: IGF2BP3
• NCBI Official Synonym Symbols: CT98; IMP3; KOC1; IMP-3; VICKZ3
• NCBI Protein Information: insulin-like growth factor 2 mRNA-binding protein 3; hKOC; VICKZ family member 3; cancer/testis antigen 98; IGF2 mRNA-binding protein 3; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH
• UniProt Protein Name: Insulin-like growth factor 2 mRNA-binding protein 3
• Protein Family: Insulin-like growth factor 2 mRNA-binding protein
• UniProt Gene Name: IGF2BP3
• UniProt Synonym Gene Names: IMP3; KOC1; VICKZ3; IGF2 mRNA-binding protein 3; IMP-3; hKOC
• UniProt Entry Name: IF2B3_HUMAN

NCBI Description

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Uniprot Description

IGF2BP3: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA. Belongs to the RRM IMP/VICKZ family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Spliceosome; Translation

Chromosomal Location of Human Ortholog: 7p11

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: anatomical structure morphogenesis; mRNA transport; translation; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process