Rabbit anti-Rat Cav2.3 Polyclonal Antibody | anti-Cav2.3 antibody

Anti-Cav2.3 (alpha1E, R-Type) Antibody

Cat. Num. AAA4159130

• Reactivity: Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: Cav2.3; Polyclonal Antibody; Anti-Cav2.3 (alpha1E; R-Type) Antibody; Ca2+ Channels; anti-Cav2.3 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: mouse, rabbit, human-respectively, 14/16, 12/16, and 11/16 residues identical.
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)

• Applicable Applications for anti-Cav2.3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: Rat brain membranes (1:200); IHC: Rat brain sections.
• Immunogen: Peptide (C)SASQ ERSLD EGVSI DG (CNE2), corresponding to residues 892-907 of rat CaV2.3 (Accession Q07652).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Related Product Information for anti-Cav2.3 antibody

Voltage-dependent Ca2+ channels (Cav channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.1 The voltage dependent Ca2+ channels are composed of several subunits; a1, b, a2d and g. Cav channels were originally divided into six physiological types: L, N, P, Q, R, and T type.1 The Cav2.3 (formerly named a1E) protein, forms the R type channels. R-type channels are highly sensitive to both SNX-482 and NiCl2. Cav3.2 channels were shown to mediate fast excitatory transmission in several synapses including the hippocampus.2 Cav2.3 channels can be modulated by the muscarinic G-protein coupled receptors. In HEK-293 cells, expressing Cav2.3 channels, the R-type channel was shown to be both facilitated and inhibited by m1 and m2 receptors. However, inhibition was much weaker than facilitation for the m1 receptor, while for m2 receptors, inhibition was much more pronounced than activation.3 Facilitation and inhibition by the same receptors was probably exerted via different pathways as was indicated by their response to various inhibitors.