Testing Data
Rabbit anti-Mouse, Rat CaVpan alpha1 Subunit Polyclonal Antibody
Anti-CaVpan alpha1 Subunit Antibody
Reactivity
Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity Purified On Immobilized Antigen.
Synonyms
CaVpan alpha1 Subunit; Polyclonal Antibody; Anti-CaVpan alpha1 Subunit Antibody; Ca2+ Channels; anti-CaVpan alpha1 Subunit antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Specificity
Cav1 family (a1C, a1D, a1F, a1S) from all known species-identical; Cav2 family (a1A, a1B, a1E) from all known species-17/19 residues identical.
Purity/Purification
Affinity Purified On Immobilized Antigen.
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Applicable Applications for anti-CaVpan alpha1 Subunit antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: Rat brain membranes (1:200)
IHC: Rat heart sections
Note: the epitope can be masked by other subunits in some Ca2+ channels.
IHC: Rat heart sections
Note: the epitope can be masked by other subunits in some Ca2+ channels.
Immunogen
Peptide (C)DNFD YLTRD WSILG PHHLD, corresponding to residues 1506-1524 of rat Cav1.2 (a 1C) (Accession P22002)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Related Product Information for anti-CaVpan alpha1 Subunit antibody
Ca2+ ions regulate many cellular processes such as secretion, proliferation, and apoptosis and they are also cofactors of many proteins.1, 2 In neurons, Ca2+ entry through voltage-dependent Ca2+ (Cav) channels triggers neurotransmitter release. Fast synaptic transmission in the mammalian central nervous system (CNS) is mediated by several high voltage-dependent Ca2+ channels.3 Five types of Ca2+ channels are expressed in the CNS: the L-type (Cav1), N-type (Cav2.2), P/Q-type (Cav2.1), R-type (Cav2.3), and the T-type (Cav3).4 Each Cav channel is a multimeric protein composed of a pore forming a1 subunit and the auxiliary b(Cavb), a2d and g subunits. There are four known Cavb subunits, in addition to four a2d subunits and eight g subunits.4 The Anti-Cavpan a1 antibody is directed against an intracellular epitope at the C-terminus of the a1 subunit recognizes the high voltage gated calcium channels, Cav1 and Cav2 subfamily members.
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Product Notes
The CaVpan alpha1 Subunit (Catalog #AAA4159134) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CaVpan alpha1 Subunit Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CaVpan alpha1 Subunit can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: Rat brain membranes (1:200) IHC: Rat heart sections Note: the epitope can be masked by other subunits in some Ca2+ channels. Researchers should empirically determine the suitability of the CaVpan alpha1 Subunit for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CaVpan alpha1 Subunit, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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