FHL2 (SLIM3) peptide
FHL2 (SLIM3)
Gene Names
FHL2; DRAL; AAG11; FHL-2; SLIM3; SLIM-3
Applications
Antibody Function Blocking
Synonyms
FHL2 (SLIM3); Four-and-a-half LIM only protein 2; FHL2 (SLIM3) peptide
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Sequence Length
279
Applicable Applications for FHL2 (SLIM3) peptide
Antibody Function Blocking
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Related Product Information for FHL2 (SLIM3) peptide
Sphingosine kinase-1 (SK1) is a key enzyme that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). SK1, and its product S1P, regulate numerous and diverse biological functions, including cell growth, differentiation, proliferation, and apoptosis. S1P also plays a central role in cardiac development and ischemic preconditioning. FHL2 (SLIM3) has been identified as a SK1-interacting protein in mammalian cardiomyocytes. FHL2, but not FHL1 or FHL3, interacts with SK1, and FHL2 colocalizes with SK1 in the cytoplasm of these cells. The interaction of FHL2 with SK-1 involves the C-terminal portion of SK1. Overexpression of FHL2 has been found to attneuate the activity and antiapoptotic effects of SK1. Endothelin-1, a potent survival factor in cardiomyocytes, inhibits FHL2-SK1 association and increases SK1 activity. FHL2 is therefore a novel inhibitor of SK1 activity in cardiomyocytes and targeting FHL2 may prevent myocardial apoptosis through activation of SK1.
Product Categories/Family for FHL2 (SLIM3) peptide
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32193 Da
NCBI Official Full Name
four and a half LIM domains protein 2
NCBI Official Synonym Full Names
four and a half LIM domains 2
NCBI Official Symbol
FHL2
NCBI Official Synonym Symbols
DRAL; AAG11; FHL-2; SLIM3; SLIM-3
NCBI Protein Information
four and a half LIM domains protein 2; LIM domain protein DRAL; aging-associated gene 11; skeletal muscle LIM-protein 3; down-regulated in rhabdomyosarcoma LIM protein
UniProt Protein Name
FHL2 protein
UniProt Gene Name
FHL2
UniProt Entry Name
Q6I9R8_HUMAN
NCBI Description
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
Uniprot Description
Sequence similarities: Contains 4 LIM zinc-binding domains. RuleBase RU000350
Research Articles on FHL2 (SLIM3)
Similar Products
Product Notes
The FHL2 (SLIM3) fhl2 (Catalog #AAA396469) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's FHL2 (SLIM3) can be used in a range of immunoassay formats including, but not limited to, Antibody Function Blocking. Researchers should empirically determine the suitability of the FHL2 (SLIM3) fhl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FHL2 (SLIM3), Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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