Western Blot/Blotting
(Western blot analysis using TUP1 antibody on recombinant TUP1 protein (amino acids 1-200) expressed in Mav108 cells.)
Mouse TUP1 Monoclonal Antibody | anti-TUP1 antibody
TUP1
Western Blot/Blotting
(Western blot analysis using TUP1 antibody on recombinant TUP1 protein (amino acids 1-200) expressed in Mav108 cells.)
Western Blot/Blotting
(Western blot analysis using TUP1 antibody on recombinant TUP1 protein (amino acids 1-200) expressed in Mav108 cells.)
NCBI and Uniprot Product Information
Uniprot Description
Function: Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex. Ref.1 Ref.11 Ref.12 Ref.13 Ref.15 Ref.16 Ref.17
Subunit structure: Associates with CYC8/SSN6 to form the CYC8-TUP1 (or TUP1-SSN6) corepressor complex that is composed of 4 copies of TUP1 and one copy of CYC8. Interacts with histone H3, histone H4, MATALPHA2, RFX1, SKO1, PGD1, HDA1, HDA2, HOS1, HOS2 AND RPD3. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15 Ref.18
Subcellular location: Nucleus Ref.19.
Miscellaneous: Present with 5840 molecules/cell in log phase SD medium.
Sequence similarities: Belongs to the WD repeat TUP1 family.Contains 7 WD repeats.
Sequence caution: The sequence CAA34411.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on TUP1
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Product Notes
The TUP1 tup1 (Catalog #AAA395028) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TUP1 reacts with Yeast (Saccharomyces cerevisiae) and may cross-react with other species as described in the data sheet. AAA Biotech's TUP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TUP1 tup1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TUP1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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