Mouse anti-Human CD14 Monoclonal Antibody | anti-CD14 antibody

CD14

Cat. Num. AAA370248

• Reactivity: Human
• Synonyms: CD14; Monoclonal Antibody; anti-CD14 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Ig2a
• Clone Number: 7
• Form/Format: CD14 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

• Control: Placenta
• Localization: Cytoplasmic, Membranous
• Reactivity Note: Paraffin, Frozen
• Preparation and Storage: Store at 2 to 8 degree C in the dark.

Dilution Information

Immunohistochemistry (IHC)

Related Product Information for anti-CD14 antibody

CD14 is a component of the innate immune system. CD14 exists in two forms. It is either anchored into the membrane by a a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can only bind LPS in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered it's main ligand CD14 also recognizes other pathogen associated molecular patterns. CD14 is expressed mainly by macrophages and (at 10 times lesser extent) by neutrophil granulocytes. A soluble form sCD14 is secreted by the liver and monocytes and is suffi cient in low concentrations to confer LPS-responsiveness to cells which otherwise do not express CD14. sCD14 is also present in human milk where it is believed to regulate microbial growth in the infant gut. Increased sCD14 levels are associated with infl ammatory infectious diseases and high mortality in gram-negative shock. CD14 also appears to be involved in clearance of gram-negative bacteria via its high affi nity binding to LPS-LPB complexes.

NCBI and Uniprot Product Information

• NCBI GI #: 2274810
• NCBI GeneID: 281048
• UniProt Accession #: Q95122; Q9TVA7; A8DBS7
• Molecular Weight: 39,667 Da
• NCBI Official Full Name: CD14
• NCBI Official Synonym Full Names: CD14 molecule<
• NCBI Official Symbol: CD14
• NCBI Protein Information: monocyte differentiation antigen CD14; CD14 antigen; myeloid cell-specific leucine-rich glycoprotein
• UniProt Protein Name: Monocyte differentiation antigen CD14
• Protein Family: Monocyte differentiation antigen
• UniProt Gene Name: CD14
• UniProt Entry Name: CD14_BOVIN

Uniprot Description

Function: In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules

By similarity.

Subunit structure: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4

By similarity.

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor

By similarity.

Sequence similarities: Contains 11 LRR (leucine-rich) repeats.