Structure
14-3-3 inhibitor BV2 Biochemical
14-3-3 inhibitor BV2
Purity
>98% (HPLC)
Synonyms
14-3-3 inhibitor BV2; 14-3-3 inhibitor BV2 biochemical
Purity/Purification
>98% (HPLC)
Target
14-3-3 Protein
Receptor
14-3-3 Protein
Chemical Name
2-((1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl)carbamoyl)terephthalic acid
SMILES
CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)C3=C(C=CC(=C3)C(=O)O)C(=O)O
Molecular Formula
C20H17N3O6
CAS Number
302602-92-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for 14-3-3 inhibitor BV2 biochemical
A novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation; induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47uM, respectively; promoted c-Abl release from 14-3-3sigma, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3sigma levels, induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib.
Product Categories/Family for 14-3-3 inhibitor BV2 biochemical
References
1. Mancini M, et al. J Pharmacol Exp Ther. 2011 Mar; 336 (3):596-604.
2. Mohammad DK, et al. Mol Cell Biol. 2013 Aug; 33 (16):3214-26.
3. Gomez-Suarez M, et al. Cell Death Differ. 2016 Jun; 23 (6):1060-72.
4. Valensin D, et al. Bioorg Med Chem Lett. 2016 Feb 1; 26 (3):894-898.
2. Mohammad DK, et al. Mol Cell Biol. 2013 Aug; 33 (16):3214-26.
3. Gomez-Suarez M, et al. Cell Death Differ. 2016 Jun; 23 (6):1060-72.
4. Valensin D, et al. Bioorg Med Chem Lett. 2016 Feb 1; 26 (3):894-898.
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Product Notes
The 14-3-3 inhibitor BV2 (Catalog #AAA3603947) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "14-3-3 inhibitor BV2, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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