Structure
NPS-1034, Inhibitor
NPS-1034
Purity
>98% (HPLC)
Synonyms
NPS-1034; NPS1034; NPS 1034; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 34mg/mL (61.65mM)
Target
AChR
Receptor
Met; AXL
Chemical Name
N-(3-fluoro-4-((3-phenyl-1H-pyrrolo[2, 3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1, 5-dimethyl-3-oxo-2, 3-dihydro-1H-pyrazole-4-carboxamide.
SMILES
CN1N(C(=O)C(C(=O)NC2=CC=C(OC3=CC=NC4=C3C(=CN4)C3=CC=CC=C3)C(F)=C2)=C1C)C1=CC=C(F)C=C1
Molecular Formula
C31H23F2N5O3
CAS Number
1221713-92-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NPS-1034, inhibitor
NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET. NPS-1034 inhibited the proliferation of cells expressing activated MET and promoted the regression of tumors formed from such cells in a mouse xenograft model through anti-angiogenic and pro-apoptotic actions. NPS-1034 also inhibited HGF-stimulated activation of MET signaling in the presence or absence of serum. Notably, NPS-1034 inhibited three MET variants that are resistant to the MET inhibitors SU11274, NVP-BVU972, and PHA665752.
Product Categories/Family for NPS-1034, inhibitor
Similar Products
Product Notes
The NPS-1034 (Catalog #AAA3607196) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NPS-1034, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
