LY2874455, Inhibitor
LY2874455
Purity
>98% (HPLC)
Synonyms
LY2874455; LY 2874455; LY-2874455; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
FGFR
Receptor
FGFR1; FGFR2; FGFR3; FGFR4; VEGFR2
Chemical Name
1H-Pyrazole-1-ethanol, 4-[(1E)-2-[5-[(1R)-1-(3, 5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]
SMILES
C[C@H](C1=C(Cl)C=NC=C1Cl)OC2=CC3=C(NN=C3/C=C/C4=CN(CCO)N=C4)C=C2
Molecular Formula
C21H19Cl2N5O2
CAS Number
1254473-64-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for LY2874455, inhibitor
LY2874455 is a potent, selective pan-FGFR inhibitor with IC50 of 2.8/2.6/6.4/6nM for FGFR1/2/3/4, respectively; inhibits FGFR2 phosphorylation in SNU-16 and KATO-III cells with IC50 of 0.8 and1.5nM, also inhibits the phosphorylation of FRS2, an immediate downstream target of FGFR, with a similar potency of 0.8 to 1.5nM; exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma. Blood Cancer Phase 1 Clinical
Product Categories/Family for LY2874455, inhibitor
References
1. Zhao G, et al. Mol Cancer Ther. 2011 Nov; 10 (11):2200-10.
2. Kim SY, et al. Oncotarget. 2017 Feb 28; 8 (9):15014-15022.
3. Michael M, et al. Target Oncol. 2017 Aug; 12 (4):463-474.
2. Kim SY, et al. Oncotarget. 2017 Feb 28; 8 (9):15014-15022.
3. Michael M, et al. Target Oncol. 2017 Aug; 12 (4):463-474.
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Product Notes
The LY2874455 (Catalog #AAA3601034) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY2874455, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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