Structure
TCASK10, Inhibitor
TCASK10
Purity
>98% (HPLC)
Synonyms
TCASK10; TCASK 10; inhibitor
Purity/Purification
>98% (HPLC)
Target
MEK
Receptor
MEK
Chemical Name
4-(1, 1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1, 2-a]pyridin-2-yl]benzamide dihydrochloride
SMILES
CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CN3C=C(C=CC3=N2)N4C=CN=C4.Cl.Cl
Molecular Formula
C21H23Cl2N5O
CAS Number
1005775-56-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for TCASK10, inhibitor
TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14nM, 30-fold selectivity over ASK2 (IC50=510nM) and no activity against MEKK1, TAK1, IKKbeta, ERK1, JNK1, p38alpha, GSK-3beta, PKCtheta and B-raf; blocks downstream JNK1/p38 phosphorylation in cells, dose-dependently reduces mitogen (FBS, PDGF and EGF)-induced airway smooth muscle (ASM) growth, also prevents TGFb1-induced migration of ASM cells in vitro.
Product Categories/Family for TCASK10, inhibitor
References
1. Terao Y, et al. Bioorg Med Chem Lett. 2012 Dec 15; 22 (24):7326-9.
2. Eapen MS, et al. Clin Sci (Lond). 2018 Jul 13. pii: CS20180398.
2. Eapen MS, et al. Clin Sci (Lond). 2018 Jul 13. pii: CS20180398.
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Product Notes
The TCASK10 (Catalog #AAA3600050) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TCASK10, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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