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Mouse beta-Tubulin mAb Antibody

beta-Tubulin antibody

Reactivity
Human, mouse, rat, monkey, Chinese hamster, dog
Applications
Western Blot, Immunofluorescence, ELISA
Synonyms
beta-Tubulin mAb; beta-Tubulin antibody; Monoclonal Anti- beta-Tubulin ; Monoclonal Anti- b-Tubulin; anti-beta-Tubulin mAb antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human, mouse, rat, monkey, Chinese hamster, dog
Specificity
Detect the endogenous levels of total beta-Tubulin protein.
Form/Format
Liquid
Applicable Applications for anti-beta-Tubulin mAb antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes
Western Blot (1:5000)
Immunofluorescence, IF (1:1000)
Immunogen
Protein fragment on C-terminal of human beta-Tubulin.
Preparation and Storage
Store at -20 degree C for 1 year. Avoid repeated freeze and thaw cycles
Related Product Information for anti-beta-Tubulin mAb antibody
Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8.1 Mutant huntingtin, disrupted intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. Mutant huntingtin impaired glucose-stimulated insulin secretion in insulin-producing beta cells, without altering stored levels of insulin. Smith et al. (2009) proposed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein.2
Product Categories/Family for anti-beta-Tubulin mAb antibody
References
1. Williams RC Jr, Shah C, Sackett D (November 1999). "Separation of tubulin isoforms by isoelectric focusing in immobilized pH gradient gels". Anal Biochem 275 (2): 265-7. 2. Smith, R., Bacos, K., Fedele, V., Soulet, D., Walz, H. A., Obermuller, S., Lindqvist, A., Bjorkqvist, M., Klein, P., Onnerfjord, P., Brundin, P., Mulder, H., Li, J.-Y. Mutant huntingtin interacts with beta-tubulin and disrupts vesicular transport and insulin secretion. Hum. Molec. Genet. 18: 3942-3954, 2009.

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Product Notes

The beta-Tubulin mAb (Catalog #AAA355045) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The beta-Tubulin antibody reacts with Human, mouse, rat, monkey, Chinese hamster, dog and may cross-react with other species as described in the data sheet. AAA Biotech's beta-Tubulin mAb can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF), ELISA (EIA). Western Blot (1:5000) Immunofluorescence, IF (1:1000). Researchers should empirically determine the suitability of the beta-Tubulin mAb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "beta-Tubulin mAb, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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