RNMT blocking peptide
RNMT Peptide - N-terminal region
Target Description: RNMT belongs to the mRNA cap methyltransferase family. RNMT is a mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. It binds RNA containing 5'-terminal GpppC.
NCBI and Uniprot Product Information
Uniprot Description
RNMT: mRNA capping methyltransferase that methylates the N7 position of the added guanosine to the 5' cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT- importin alpha to bind RNA substrates.Interacts with elongating form of polymerase II and RNGTT. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; RNA processing; EC 2.1.1.56
Chromosomal Location of Human Ortholog: 18p11.21
Cellular Component: nucleoplasm; mRNA cap complex; nucleolus; nucleus; receptor complex
Molecular Function: protein binding; RNA binding; mRNA (guanine-N7-)-methyltransferase activity
Biological Process: transcription from RNA polymerase II promoter; mRNA capping; viral reproduction; gene expression
Research Articles on RNMT
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Product Notes
The RNMT rnmt (Catalog #AAA3230237) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's RNMT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the RNMT rnmt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RNMT, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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