Western Blot (WB)
(WB Suggested Anti-MCPH1 AntibodyTitration: 1.0 ug/mlPositive Control: Hela Whole Cell)
Rabbit anti-Human MCPH1 Polyclonal Antibody | anti-MCPH1 antibody
MCPH1 antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-MCPH1 AntibodyTitration: 1.0 ug/mlPositive Control: Hela Whole Cell)
Western Blot (WB)
(WB Suggested Anti-MCPH1 AntibodyTitration: 1.0 ug/mlPositive Control: Hela Whole Cell)
Target Description: This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Uniprot Description
MCPH1: a DNA damage responsive protein and transcriptional repressor of human telomere reverse transcriptase. An early responder to DNA damage. Required for double strand break repair via homologous recombination and nonhomologous end joining. Promotes chromatin relaxation by recruiting and maintaining the chromatin remodeling SWI-SNF complex at sites of DNA double strand breakage. Participates in the ATR/Chk1-mediated DNA checkpoint in humans and transcriptionally regulates BRCA1 and Chk1. Plays a role in neurogenesis and regulation of the size of the cerebral cortex. Mutations of MCPH1 can cause microcephaly in humans and appears to play an evolutionarily conserved role in brain development. Alterations have been identified in breast, ovarian and prostate cancer. Appears to coordinate S-M transitions in fly embryos.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center
Molecular Function: identical protein binding; protein binding
Biological Process: mitotic cell cycle; cerebral cortex development
Disease: Microcephaly 1, Primary, Autosomal Recessive
Research Articles on MCPH1
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Product Notes
The MCPH1 mcph1 (Catalog #AAA3216197) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MCPH1 antibody - C-terminal region reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MCPH1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the MCPH1 mcph1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: VLDDSCDGFK DLIKPHEELK KSGRGKKPTR TLVMTSMPSE KQNVVIQVVD. It is sometimes possible for the material contained within the vial of "MCPH1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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