Western Blot (WB)
(Host: RabbitTarget Name: Ddit4Sample Type: Rat Thymus lysatesAntibody Dilution: 1.0ug/ml)
Rabbit Ddit4 Polyclonal Antibody | anti-DDIT4 antibody
Ddit4 Antibody - N-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: Ddit4Sample Type: Rat Thymus lysatesAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: Ddit4Sample Type: Rat Thymus lysatesAntibody Dilution: 1.0ug/ml)
Target Description: Ddit4 is a HIF-1-responsive gene that may protect some types of cells from hypoxia and H(2)O(2)-triggered apoptosis.
NCBI and Uniprot Product Information
NCBI Description
HIF-1-responsive gene that may protect some types of cells from hypoxia and H(2)O(2)-triggered apoptosis [RGD, Feb 2006]
Uniprot Description
DDIT4: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family.
Chromosomal Location of Human Ortholog: 20q11
Cellular Component: cytoplasm; cytosol; intracellular; mitochondrion
Biological Process: apoptosis; brain development; cell proliferation; defense response to virus; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of glycolytic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of TOR signaling; nerve growth factor receptor signaling pathway; neuron differentiation; neuron migration; protein complex disassembly; response to hypoxia
Research Articles on DDIT4
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Product Notes
The DDIT4 ddit4 (Catalog #AAA3213300) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ddit4 Antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Ddit4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the DDIT4 ddit4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: SLESSDCESL DSSNSGFGPE EDSSYLDGVS LPDFELLSDP EDEHLCANLM. It is sometimes possible for the material contained within the vial of "Ddit4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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