Immunohistochemistry (IHC)
(Human kidney )
Rabbit MAS1 Polyclonal Antibody | anti-MAS1 antibody
MAS1 antibody - middle region
Immunohistochemistry (IHC)
(Human kidney )
Immunohistochemistry (IHC)
(Human kidney )
Western Blot (WB)
(Host: RabbitTarget Name: MAS1Sample Tissue: Human DLD1Antibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: MAS1Sample Tissue: Human DLD1Antibody Dilution: 1.0ug/ml)
Western Blot (WB)
(WB Suggested Anti-MAS1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate)
Western Blot (WB)
(WB Suggested Anti-MAS1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate)
Target Description: The structure of MAS1 indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
Uniprot Description
MAS1: Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family.
Protein type: Oncoprotein; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6q25.3-q26
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; angiotensin type II receptor activity; peptide hormone binding; peptide binding; angiotensin receptor activity
Biological Process: response to drug; anatomical structure morphogenesis; male gonad development; hippocampus development; activation of NF-kappaB-inducing kinase; cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of protein amino acid phosphorylation; regulation of inflammatory response; positive regulation of cell proliferation; spermatogenesis; response to activity; positive regulation of DNA replication
Research Articles on MAS1
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Product Notes
The MAS1 mas1 (Catalog #AAA3210241) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MAS1 antibody - middle region reacts with Guinea Pig, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's MAS1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the MAS1 mas1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: RPKYQSALVC ALLWALSCLV TTMEYVMCID REEESHSRND CRAVIIFIAI. It is sometimes possible for the material contained within the vial of "MAS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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