Rabbit anti-Human MAS1 Polyclonal Antibody | anti-MAS1 antibody

MAS1 Antibody (C-term)

Cat. Num. AAA9202317

• Gene Names: MAS1; MAS; MGRA
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: MAS1; Polyclonal Antibody; MAS1 Antibody (C-term); Proto-oncogene Mas; MAS; anti-MAS1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This MAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human MAS1.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.35 (varies by lot)
• Sequence Positions: 285-314
• Sequence Length: 325

• Applicable Applications for anti-MAS1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(MAS1 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MAS1 antibody detected the MAS1 protein (arrow).)

Related Product Information for anti-MAS1 antibody

The structure of the MAS1 product indicates that it
belongs to the class of receptors that are coupled to GTP-binding
proteins and share a conserved structural motif, which is described
as a '7-transmembrane segment' following the prediction that these
hydrophobic segments form membrane-spanning alpha-helices. The MAS1
protein may be a receptor that, when activated, modulates a
critical component in a growth-regulating pathway to bring about
oncogenic effects.

Product Categories/Family for anti-MAS1 antibody

Cancer; Cell Biology; Signal Transduction; Phospho Antibodies

References

Yang, J.K., et al. Diabetes Care 33(10):2271-2273(2010)
Reis, A.B., et al. J. Mol. Histol. 41(1):75-80(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Iwai, M., et al. Hypertens. Res. 32(7):533-536(2009)
Vaz-Silva, J., et al. Reprod Sci 16(3):247-256(2009)

NCBI and Uniprot Product Information

• NCBI GI #: 4505105
• NCBI GeneID: 4142
• NCBI Accession #: NP_002368.1
• NCBI GenBank Nucleotide #: NM_002377.2
• UniProt Accession #: P04201; Q2TBC9; Q6FG47; E1P5B3
• Molecular Weight: 37465
• NCBI Official Full Name: proto-oncogene Mas
• NCBI Official Synonym Full Names: MAS1 proto-oncogene, G protein-coupled receptor
• NCBI Official Symbol: MAS1
• NCBI Official Synonym Symbols: MAS; MGRA
• NCBI Protein Information: proto-oncogene Mas
• UniProt Protein Name: Proto-oncogene Mas
• Protein Family: Proto-oncogene
• UniProt Gene Name: MAS1
• UniProt Synonym Gene Names: MAS
• UniProt Entry Name: MAS_HUMAN

NCBI Description

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

Uniprot Description

MAS1: Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Oncoprotein; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 6q25.3-q26

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; angiotensin type II receptor activity; peptide hormone binding; peptide binding; angiotensin receptor activity

Biological Process: response to drug; G-protein coupled receptor protein signaling pathway; cell proliferation; anatomical structure morphogenesis; negative regulation of protein amino acid phosphorylation; hippocampus development; regulation of inflammatory response; male gonad development; positive regulation of cell proliferation; activation of NF-kappaB-inducing kinase; spermatogenesis; response to activity; positive regulation of DNA replication