anti-Human CD24 Monoclonal Antibody | anti-CD24 antibody
MAb to CD24
Source: Ascites
CD 24. The molecular weight of the recognized antigen is 35-45kDa. Recognizes B cells from pre-B to mature-B stage. The ALB9 monoclonal antibody has been assigned to the CD24 cluster of differentiation at the sixth International Workshop on Human
Reconstitute with 1ml distilled water.
Immunohistochemistry (frozen sections or cell smears)
Studies of peripheral blood B cells.
Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but
• Duperray, C., et al., (1990), "The CD24 antigen discriminates between pre-B and B cells in huma
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. [provided by RefSeq]
Uniprot Description
Function: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. Ref.7
Subunit structure: Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma. Ref.6 Ref.7
Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity: B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. Ref.6 Ref.9
Induction: Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.
Post-translational modification: Extensively O-glycosylated.
Involvement in disease: Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [
MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. Ref.9
Sequence similarities: Belongs to the CD24 family.
Sequence caution: The sequence AAD14170.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on CD24
Similar Products
Product Notes
The CD24 cd24 (Catalog #AAA311968) is an Antibody produced from Host: Mouse. Hybridization of NS/Ag.4.1 myeloma cells with spleen cells from BALB/c mice. Source: Ascites and is intended for research purposes only. The product is available for immediate purchase. The MAb to CD24 reacts with Human and may cross-react with other species as described in the data sheet. Flow cytometry Immunohistochemistry (frozen sections or cell smears) Studies of peripheral blood B cells. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but. Researchers should empirically determine the suitability of the CD24 cd24 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD24, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
