Rabbit FYB Polyclonal Antibody | anti-FYB antibody

FYB polyclonal antibody

Cat. Num. AAA3014960

• Gene Names: FYB; ADAP; PRO0823; SLAP130; SLAP-130
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Synonyms: FYB; Polyclonal Antibody; FYB polyclonal antibody; ADAP; p120/p130; FYB1; SLAP130; Adhesion and degranulation promoting adaptor protein; ; Fyb; FYB-120/130; FYN binding protein; FYN-binding protein; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein; anti-FYB antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: FYB polyclonal antibody detects endogenous levels of FYB protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-FYB antibody: Western Blot (WB)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:200
• Immunogen: Synthetic peptide, corresponding to Human FYB
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of FYB polyclonal antibody at 1:500 dilutionLaneA: H9C2 whole cell lysateLaneB: SP2/0 whole cell lysateLaneC: PC3 whole cell lysate)

Related Product Information for anti-FYB antibody

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 42476118
• NCBI GeneID: 2533
• NCBI Accession #: NP_001456
• NCBI GenBank Nucleotide #: NM_001465.4
• UniProt Accession #: O15117; O00359; Q9NZI9; A8K2Y8; B4DLN2; E9PBV9
• Molecular Weight: 91,651 Da
• NCBI Official Full Name: FYN-binding protein isoform 1
• NCBI Official Synonym Full Names: FYN binding protein
• NCBI Official Symbol: FYB
• NCBI Official Synonym Symbols: ADAP; PRO0823; SLAP130; SLAP-130
• NCBI Protein Information: FYN-binding protein; p120/p130; FYB-120/130; FYN-T-binding protein; SLP-76-associated phosphoprotein; adhesion and degranulation-promoting adaptor protein
• UniProt Protein Name: FYN-binding protein
• Protein Family: FYN-binding protein
• UniProt Gene Name: FYB
• UniProt Synonym Gene Names: SLAP130; ADAP; p120/p130
• UniProt Entry Name: FYB_HUMAN

NCBI Description

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Description

SLAP-130: an adapter protein for fyn and the SH2-domain-containing leucocyte protein-76 (SLP76) in T cells. T-cell receptor ligation leads to increased tyrosine phosphorylation of SLAP-130. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: cytosol; nucleus; actin cytoskeleton

Molecular Function: protein binding; protein complex binding; receptor binding

Biological Process: immune response; NLS-bearing substrate import into nucleus; signal transduction; T cell receptor signaling pathway; protein amino acid phosphorylation