MRP2 blocking peptide

MRP2 Peptide

Cat. Num. AAA3005993

• Gene Names: ABCC2; DJS; MRP2; cMRP; ABC30; CMOAT
• Applications: Blocking
• Purity: Synthetic peptide MRP2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: MRP2; MRP2 Peptide; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2; ABCC2; CMOAT; CMOAT1; CMRP; MRP2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3005992 MRP2 pAb.
• Purity/Purification: Synthetic peptide MRP2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1545

• Applicable Applications for MRP2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for MRP2 blocking peptide

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the Mdr-1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter), and MRP3, which are both conjugate export pumps ex-pressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also mediates the transport of the organic anion S-(2, 4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues, yet at much lower levels of expression.

NCBI and Uniprot Product Information

• NCBI GI #: 4557481
• NCBI GeneID: 1244
• NCBI Accession #: NP_000383.1
• NCBI GenBank Nucleotide #: NP_000383.1
• UniProt Accession #: Q92887
• NCBI Official Full Name: canalicular multispecific organic anion transporter 1
• NCBI Official Synonym Full Names: ATP binding cassette subfamily C member 2
• NCBI Official Symbol: ABCC2
• NCBI Official Synonym Symbols: DJS; MRP2; cMRP; ABC30; CMOAT
• NCBI Protein Information: canalicular multispecific organic anion transporter 1
• UniProt Protein Name: Canalicular multispecific organic anion transporter 1
• Protein Family: 37S ribosomal protein
• UniProt Gene Name: ABCC2
• UniProt Synonym Gene Names: CMOAT; CMOAT1; CMRP; MRP2
• UniProt Entry Name: MRP2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCC2: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: intercellular canaliculus; cell surface; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: protein domain specific binding; protein binding; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: prostaglandin transport; metabolic process; response to heat; response to estrogen stimulus; transport; response to arsenic; multidrug transport; response to methotrexate; response to oxidative stress; cellular chloride ion homeostasis; transmembrane transport

Disease: Dubin-johnson Syndrome