Testing Data
(Rat lung tissue was stained by Rabbit Anti-PAMP-20 (rat) Antibody)
Rabbit anti-Rat Adrenomedullin N-20, Pro Polyclonal Antibody | anti-ADM antibody
Adrenomedullin N-20, Pro (Proadrenomedullin N-20 Terminal Peptide, ProAM N-terminal 20 Peptide, PAMP, ProAM-N20)
Serum
Serum
Dilution: Immunohistochemistry (formalin-fixed paraffin): 1:500 (DAB)
Testing Data
(Rat lung tissue was stained by Rabbit Anti-PAMP-20 (rat) Antibody)
Testing Data
(Rat lung tissue was stained by Rabbit Anti-PAMP-20 (rat) Antibody)
Testing Data
(Rat lung tissue was stained by Rabbit Anti-PAMP-20 (rat) Antibody)
Testing Data
(Rat lung tissue was stained by Rabbit Anti-PAMP-20 (rat) Antibody)
NCBI and Uniprot Product Information
NCBI Description
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Subcellular location: Secreted.
Tissue specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
Sequence similarities: Belongs to the adrenomedullin family.
Research Articles on ADM
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Product Notes
The ADM adm (Catalog #AAA647790) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Adrenomedullin N-20, Pro (Proadrenomedullin N-20 Terminal Peptide, ProAM N-terminal 20 Peptide, PAMP, ProAM-N20) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Adrenomedullin N-20, Pro can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry. Dilution: Immunohistochemistry (formalin-fixed paraffin): 1:500 (DAB). Researchers should empirically determine the suitability of the ADM adm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Ala-Arg-Le u-Asp-Thr- Ser-Ser-Gl n-Phe-Arg- Lys-Lys-Tr p-Asn-Lys- Trp-Ala-Le u-Ser-Arg- NH2. It is sometimes possible for the material contained within the vial of "Adrenomedullin N-20, Pro, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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