Kir5.1 blocking peptide

Kir5.1 (N410) Peptide

Cat. Num. AAA3003298

• Applications: Blocking
• Purity: Synthetic peptide Kir5.1 (N410). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Kir5.1; Kir5.1 (N410) Peptide; KCNJ16; Kir5.1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3003297 Kir5.1 (N410) pAb.
• Purity/Purification: Synthetic peptide Kir5.1 (N410). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 418

• Applicable Applications for Kir5.1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Kir5.1 blocking peptide

The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as KIR1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as KIR1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas. The gene encoding human KIR5.1 maps to chromosome 17.

NCBI and Uniprot Product Information

• NCBI GI #: 8923823
• NCBI Accession #: NP_061128.1
• NCBI GenBank Nucleotide #: NP_061128.1
• UniProt Accession #: Q9NPI9
• NCBI Official Full Name: inward rectifier potassium channel 16
• UniProt Protein Name: Inward rectifier potassium channel 16
• UniProt Gene Name: KCNJ16
• UniProt Entry Name: KCJ16_HUMAN

Uniprot Description

Kir5.1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane

Molecular Function: inward rectifier potassium channel activity

Biological Process: synaptic transmission; potassium ion import; potassium ion transport