Rabbit KCNJ15 Polyclonal Antibody | anti-KCNJ15 antibody

KCNJ15 Polyclonal Antibody

Cat. Num. AAA3006933

• Gene Names: KCNJ15; IRKK; KIR1.3; KIR4.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KCNJ15; Polyclonal Antibody; KCNJ15 Polyclonal Antibody; ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+) channel Kir1.3; Inward rectifier K(+) channel Kir4.2; Potassium channel; inwardly rectifying subfamily J member 15; KCNJ14; anti-KCNJ15 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KCNJ15 polyclonal antibody detects endogenous levels of KCNJ15 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 375

• Applicable Applications for anti-KCNJ15 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human KCNJ15
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of KCNJ15 polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate)

Related Product Information for anti-KCNJ15 antibody

The KIR (inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. Kir4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. Kir4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human Kir4.1 maps to chromosome 1. Kir4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human Kir4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and Kir4.2 may play a role in the pathogenesis of Downs syndrome. Kir 5.1 forms functional channels only by coexpression with either Kir4.1 or Kir4.2 in the kidney and pancreas. The gene encoding human Kir5.1 maps to chromosome 17.

NCBI and Uniprot Product Information

• NCBI GI #: 449310816
• NCBI GeneID: 3772
• NCBI Accession #: NP_001263368.1
• NCBI GenBank Nucleotide #: NP_001263368.1
• UniProt Accession #: Q99712
• Molecular Weight: ~ 43kDa
• NCBI Official Full Name: ATP-sensitive inward rectifier potassium channel 15
• NCBI Official Synonym Full Names: potassium inwardly rectifying channel subfamily J member 15
• NCBI Official Symbol: KCNJ15
• NCBI Official Synonym Symbols: IRKK; KIR1.3; KIR4.2
• NCBI Protein Information: ATP-sensitive inward rectifier potassium channel 15
• UniProt Protein Name: ATP-sensitive inward rectifier potassium channel 15
• Protein Family: ATP-sensitive inward rectifier potassium channel
• UniProt Gene Name: KCNJ15
• UniProt Synonym Gene Names: KCNJ14

NCBI Description

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

Uniprot Description

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.