Rabbit anti-Human KIF20A Polyclonal Antibody | anti-KIF20A antibody

KIF20A (I524) Polyclonal Antibody

Cat. Num. AAA3003295

• Gene Names: KIF20A; MKLP2; RAB6KIFL
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: KIF20A; Polyclonal Antibody; KIF20A (I524) Polyclonal Antibody; Kinesin-like protein KIF20A; GG10_2; Mitotic kinesin-like protein 2; MKlp2; Rab6-interacting kinesin-like protein; Rabkinesin-6; MKLP2; RAB6KIFL; anti-KIF20A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: KIF20A (I524) polyclonal antibody detects endogenous levels of KIF20A protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 890

• Applicable Applications for anti-KIF20A antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 501-550 of Human KIF20A.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of KIF20A (I524) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Related Product Information for anti-KIF20A antibody

KIF20A is a member of the kinesin-like protein family and has 1 kinesin motor domain. It interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B and may act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. KIF20A has a microtubule plus end-directed motility.

NCBI and Uniprot Product Information

• NCBI GI #: 5032013
• NCBI GeneID: 10112
• NCBI Accession #: NP_005724.1
• NCBI GenBank Nucleotide #: NP_005724.1
• UniProt Accession #: O95235
• Molecular Weight: ~ 100kDa
• NCBI Official Full Name: kinesin-like protein KIF20A
• NCBI Official Synonym Full Names: kinesin family member 20A
• NCBI Official Symbol: KIF20A
• NCBI Official Synonym Symbols: MKLP2; RAB6KIFL
• NCBI Protein Information: kinesin-like protein KIF20A
• UniProt Protein Name: Kinesin-like protein KIF20A
• Protein Family: Kinesin-like protein
• UniProt Gene Name: KIF20A
• UniProt Synonym Gene Names: MKLP2; RAB6KIFL; MKlp2
• UniProt Entry Name: KI20A_HUMAN

Uniprot Description

KIF20A: Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. Belongs to the kinesin-like protein family.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: nucleoplasm; Golgi apparatus; kinesin complex; microtubule; spindle; midbody

Molecular Function: protein binding; transporter activity; microtubule binding; ATPase activity; microtubule motor activity; protein kinase binding; ATP binding

Biological Process: vesicle-mediated transport; protein transport; cytokinesis after mitosis; cell separation during cytokinesis; metabolic process; cytokinesis; mitotic cell cycle; microtubule-based movement; microtubule bundle formation