EMR2 blocking peptide

EMR2 (L160) Peptide

Cat. Num. AAA3002854

• Gene Names: ADGRE2; VBU; CD97; EMR2; CD312
• Applications: Blocking
• Purity: Synthetic peptide EMR2 (L160). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: EMR2; EMR2 (L160) Peptide; EGF-like module-containing mucin-like hormone receptor-like 2; EGF-like module receptor 2; CD312; EMR2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002853 EMR2 (L160) pAb.
• Purity/Purification: Synthetic peptide EMR2 (L160). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 823

• Applicable Applications for EMR2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for EMR2 blocking peptide

EMR2 is a member of the EGF-TM7 receptor subfamily. EGF-TM7 receptors are a family of class B, seven-span transmembrane (TM7) receptors predominantly expressed by cells of the immune system. Within the TM7 superfamily, the molecular structure and ligand-binding properties of EGF-TM7 receptors are unique. Derived from the processing of a single polypeptide, they are expressed at the cell surface as heterodimers consisting of a large extracellular region associated with a TM7 moiety. Through a variable number of N-terminal EGF-like domains, EGF-TM7 receptors interact with cellular ligands such as CD55 and chondroitin sulfate. EMR2 is a heptahelical molecule predominantly expressed on cells of the immune system such as leukocytes. EMR2 is proteolytically cleaved into two separate subunits: a seven-transmembrane subunit, and an extracellular alpha subunit.

NCBI and Uniprot Product Information

• NCBI GI #: 23397681
• NCBI GeneID: 30817
• NCBI Accession #: NP_038475.2
• NCBI GenBank Nucleotide #: NP_038475.2
• UniProt Accession #: Q9UHX3
• NCBI Official Full Name: adhesion G protein-coupled receptor E2 isoform a
• NCBI Official Synonym Full Names: adhesion G protein-coupled receptor E2
• NCBI Official Symbol: ADGRE2
• NCBI Official Synonym Symbols: VBU; CD97; EMR2; CD312
• NCBI Protein Information: adhesion G protein-coupled receptor E2
• UniProt Protein Name: EGF-like module-containing mucin-like hormone receptor-like 2
• UniProt Gene Name: EMR2
• UniProt Entry Name: EMR2_HUMAN

NCBI Description

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Uniprot Description

EMR2: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 2; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell migration; cell adhesion; inflammatory response