Rabbit TFAP2C Polyclonal Antibody | anti-TFAP2C antibody

TFAP2C Antibody

Cat. Num. AAA7115934

• Gene Names: TFAP2C; ERF1; TFAP2G; hAP-2g; AP2-GAMMA
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: TFAP2C; Polyclonal Antibody; TFAP2C Antibody; Transcription factor AP-2 gamma; AP2-gamma; Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1; anti-TFAP2C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; In Phosphate Buffered Saline, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.

• Applicable Applications for anti-TFAP2C antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:100-1:300; ELISA: 1:40000
• Immunogen: Synthesized peptide derived from the C-terminal region of human AP-2gamma.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western Blot analysis of HuvEc cells using AP-2gamma Polyclonal Antibody)

Product Categories/Family for anti-TFAP2C antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 4507445
• NCBI GeneID: 7022
• NCBI Accession #: NP_003213.1
• NCBI GenBank Nucleotide #: NM_003222.3
• UniProt Accession #: Q92754; O00685; O00730; Q86V30; Q8IVB6; Q9P1X2
• Molecular Weight: 49,177 Da
• NCBI Official Full Name: transcription factor AP-2 gamma
• NCBI Official Synonym Full Names: transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
• NCBI Official Symbol: TFAP2C
• NCBI Official Synonym Symbols: ERF1; TFAP2G; hAP-2g; AP2-GAMMA
• NCBI Protein Information: transcription factor AP-2 gamma; estrogen receptor factor 1; transcription factor ERF-1; activating enhancer-binding protein 2 gamma; transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma)
• UniProt Protein Name: Transcription factor AP-2 gamma
• Protein Family: Transcription factor
• UniProt Gene Name: TFAP2C
• UniProt Synonym Gene Names: AP2-gamma
• UniProt Entry Name: AP2C_HUMAN

NCBI Description

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]

Uniprot Description

AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family.

Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: nucleus

Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; male gonad development; sebaceous gland development; germ-line stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; trophectodermal cell differentiation; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; hair follicle development; cell-cell signaling; positive regulation of transcription from RNA polymerase II promoter; forebrain neuron fate commitment; cerebral cortex development; regulation of epidermis development