Rabbit EMR2 Polyclonal Antibody | anti-EMR2 antibody

Rabbit Polyclonal to Human EMR2

Cat. Num. AAA243493

• Gene Names: EMR2; CD312
• Reactivity: Gorilla, Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: EMR2; Polyclonal Antibody; Rabbit Polyclonal to Human EMR2; Anti-EMR2 Antibody (N-Terminus) IHC-plus; CD312 antigen; EGF-like module receptor 2; CD312; Human EMR2; anti-EMR2 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human
• Clonality: Polyclonal
• Specificity: Human EMR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 823

• Applicable Applications for anti-EMR2 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (17 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human EMR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: EMR2 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human EMR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-EMR2 antibody IHC of human lung, pneumonia, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-EMR2 antibody

EMR2 is an Orphan-B GPCR with an unknown ligand. EMR2 has five EGF-like domains in the extracellular domain and is highly homologous to CD97. Multiple isoforms of EMR2 are produced by alternative splicing.

Product Categories/Family for anti-EMR2 antibody

Family: GPCR; Subfamily: Orphan-B

NCBI and Uniprot Product Information

• NCBI GI #: 23397681
• NCBI GeneID: 30817
• NCBI Accession #: NP_038475.2
• NCBI GenBank Nucleotide #: NM_013447.3
• UniProt Accession #: Q9UHX3; Q8NG96; Q9Y4B1; B4DQ96; E7ESD7; E9PBR1; E9PEL6; E9PFQ5; E9PG91
• Molecular Weight: 84,079 Da
• NCBI Official Full Name: EGF-like module-containing mucin-like hormone receptor-like 2 isoform a
• NCBI Official Synonym Full Names: egf-like module containing, mucin-like, hormone receptor-like 2
• NCBI Official Symbol: EMR2
• NCBI Official Synonym Symbols: CD312
• NCBI Protein Information: EGF-like module-containing mucin-like hormone receptor-like 2
• UniProt Protein Name: EGF-like module-containing mucin-like hormone receptor-like 2
• UniProt Gene Name: EMR2
• UniProt Entry Name: EMR2_HUMAN

NCBI Description

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Uniprot Description

EMR2: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell migration; inflammatory response; cell adhesion