UMP-CMP Kinase Blocking Peptide | UMP-CMP blocking peptide

UMP-CMP Kinase (E36) Peptide

Cat. Num. AAA3001974

• Gene Names: CMPK1; CK; CMK; UMK; CMPK; UMPK; UMP-CMPK
• Applications: Blocking
• Purity: Synthetic peptide UMP-CMP Kinase (E36). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: UMP-CMP Kinase; UMP-CMP Kinase (E36) Peptide; UCK; UMK; UMP CMP; UMP CMP kinase; UMP-CMP kinase; UMP/CMP kinase; UMP/CMPK; UMPK; CMK; CMPK 1; CMPK; cmpk1; UMP-CMP blocking peptide

• Specificity: This peptide can be used with studies using MBS3001973 UMP-CMP Kinase (E36) pAb.
• Purity/Purification: Synthetic peptide UMP-CMP Kinase (E36). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 179

• Applicable Applications for UMP-CMP blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for UMP-CMP blocking peptide

Nucleoside monophosphate kinases are required for pharmacological activation of therapeutic nucleosides and nucleotide analogs. CMPK (Cytidine monophosphate kinase), also known as UMP-CMP kinase and Deoxycytidylate kinase, is a 196 amino acid protein that catalyzes the phosphoryl transfer from ATP to UMP, CMP and dCMP. This enzymatic reaction leads to the formation of ADP and the corresponding nucleoside diphosphate, which are required for cellular nucleic acid synthesis. Primarily localized to the cytoplasm, CMPK also plays an important role in the activation of pyrimidine analogs, which is clinically useful anti-cancer and anti-viral drugs. CMP is the best substrate for CMPK, followed by UMP and dCMP.

NCBI and Uniprot Product Information

• NCBI GI #: 209915597
• NCBI GeneID: 51727
• NCBI Accession #: NP_001129612.1
• NCBI GenBank Nucleotide #: NP_001129612.1
• UniProt Accession #: P30085
• NCBI Official Full Name: UMP-CMP kinase isoform b
• NCBI Official Synonym Full Names: cytidine/uridine monophosphate kinase 1
• NCBI Official Symbol: CMPK1
• NCBI Official Synonym Symbols: CK; CMK; UMK; CMPK; UMPK; UMP-CMPK
• NCBI Protein Information: UMP-CMP kinase
• UniProt Protein Name: UMP-CMP kinase
• Protein Family: UMP-CMP kinase
• UniProt Gene Name: CMPK1
• UniProt Synonym Gene Names: CMK; CMPK; UCK; UMK; UMPK; CK; dCMP kinase; UMP/CMP kinase; UMP/CMPK
• UniProt Entry Name: KCY_HUMAN

NCBI Description

This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Description

CMPK: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP. Belongs to the adenylate kinase family.

Protein type: EC 2.7.4.14; Nucleotide Metabolism - pyrimidine; Kinase, other; EC 2.7.4.6

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: uridine kinase activity; UMP kinase activity; nucleoside diphosphate kinase activity; cytidylate kinase activity; ATP binding

Biological Process: nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; UMP biosynthetic process; phthalate metabolic process; pyrimidine ribonucleotide biosynthetic process; nucleoside diphosphate phosphorylation; UDP biosynthetic process; ovulation cycle process; 'de novo' pyrimidine base biosynthetic process; CDP biosynthetic process; dUDP biosynthetic process; nucleoside triphosphate biosynthetic process; dCDP biosynthetic process