RARRES2 / Retinoic Acid Receptor Responder Protein 2 Recombinant Protein | RARRES2 recombinant protein

Human RARRES2 / Retinoic Acid Receptor Responder Protein 2 Recombinant Protein

• Gene Names: RARRES2; TIG2; HP10433
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: RARRES2 / Retinoic Acid Receptor Responder Protein 2; Human RARRES2 / Retinoic Acid Receptor Responder Protein 2 Recombinant Protein; Retinoic acid receptor responder protein 2; Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein; TIG2; RARRES2 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 163

• Applicable Applications for RARRES2 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Entry Function: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 4506427
• NCBI GeneID: 5919
• NCBI Accession #: NP_002880.1
• NCBI GenBank Nucleotide #: NP_002880.1
• UniProt Accession #: Q99969
• NCBI Official Full Name: retinoic acid receptor responder protein 2
• NCBI Official Synonym Full Names: retinoic acid receptor responder 2
• NCBI Official Symbol: RARRES2
• NCBI Official Synonym Symbols: TIG2; HP10433
• NCBI Protein Information: retinoic acid receptor responder protein 2
• UniProt Protein Name: Retinoic acid receptor responder protein 2
• Protein Family: Retinoic acid receptor responder protein
• UniProt Gene Name: RARRES2
• UniProt Synonym Gene Names: TIG2
• UniProt Entry Name: RARR2_HUMAN

NCBI Description

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]

Uniprot Description

RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: extracellular matrix; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: positive regulation of chemotaxis; in utero embryonic development; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; inflammatory response; retinoid metabolic process; chemotaxis; embryonic gut development; regulation of lipid catabolic process