Mouse Low affinity immunoglobulin gamma Fc region receptor II ELISA Kit | Fcgr2 elisa kit

Mouse Low affinity immunoglobulin gamma Fc region receptor II ELISA Kit

Cat. Num. AAA288526

• Gene Names: Fcgr2b; CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; AI528646; Fc[g]RII; F630109E10Rik
• Reactivity: Mouse
• Synonyms: Low affinity immunoglobulin gamma Fc region receptor II; Mouse Low affinity immunoglobulin gamma Fc region receptor II ELISA Kit; Fcgr2 elisa kit

• Reactivity: Mouse
• Specificity: This assay recognizes recombinant and natural mouse Low affinity immunoglobulin gamma Fc region receptor II. No significant cross-reactivity or interference was observed.
• Sequence Length: 341

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/ml
• Sensitivity: 0.188 ng/mL
• Intra-Assay CV: <=3.6%
• Inter-Assay CV: <=5.7%
• Recovery: 101%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for Fcgr2 elisa kit

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to Low affinity immunoglobulin gamma Fc region receptor II. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated polyclonal antibody preparation specific for Low affinity immunoglobulin gamma Fc region receptor II and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain Low affinity immunoglobulin gamma Fc region receptor II, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of Low affinity immunoglobulin gamma Fc region receptor II in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 6857783
• NCBI GeneID: 14130
• NCBI Accession #: NP_034317.1
• NCBI GenBank Nucleotide #: NM_010187.2
• UniProt Accession #: P08101; P08102; P12316; P97917; Q60938; Q60939; Q60940; Q61170; Q61558
• Molecular Weight: – Da
• NCBI Official Full Name: low affinity immunoglobulin gamma Fc region receptor II-b isoform 2
• NCBI Official Synonym Full Names: Fc receptor, IgG, low affinity IIb
• NCBI Official Symbol: Fcgr2b
• NCBI Official Synonym Symbols: CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; AI528646; Fc[g]RII; F630109E10Rik
• NCBI Protein Information: low affinity immunoglobulin gamma Fc region receptor II-b
• UniProt Protein Name: Low affinity immunoglobulin gamma Fc region receptor II
• Protein Family: Low affinity immunoglobulin gamma Fc region receptor
• UniProt Gene Name: Fcgr2
• UniProt Synonym Gene Names: Fcgr2b; Ly-17; Fc-gamma RII; Fc-gamma-RIIB; FcRII; Ly-17
• UniProt Entry Name: FCGR2_MOUSE

Uniprot Description

FCGR2B: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.

Protein type: Membrane protein, integral; Oncoprotein; Cell surface

Cellular Component: cell surface; cytoplasm; cytoskeleton; external side of plasma membrane; extracellular region; integral to membrane; integral to plasma membrane; lipid raft; membrane; plasma membrane; recycling endosome

Molecular Function: IgG binding; immunoglobulin binding; protein binding; receptor signaling protein activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor linked signal transduction; defense response; endocytic recycling; immune complex clearance; immune response; immunoglobulin mediated immune response; mast cell activation; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of B cell proliferation; negative regulation of humoral immune response mediated by circulating immunoglobulin; negative regulation of immune response; negative regulation of immunoglobulin production; negative regulation of inflammatory response to antigenic stimulus; negative regulation of interleukin-10 production; negative regulation of neutrophil apoptosis; negative regulation of phagocytosis; negative regulation of type I hypersensitivity; phagocytosis, engulfment; positive regulation of phagocytosis; receptor-mediated endocytosis; response to bacterium