Typical Testing Data/Standard Curve (for reference only)
Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ELISA Kit | Atp2a1 elisa kit
Mouse Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
ATP2A1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Associated with sarcolipin (SLN) and phospholamban (PLN). Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. Skeletal muscle, fast twitch muscle (type II) fibers. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, ion channel; Endoplasmic reticulum; Membrane protein, integral; EC 3.6.3.8; Hydrolase
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; I band; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; membrane; mitochondrion; sarcoplasmic reticulum; sarcoplasmic reticulum membrane
Molecular Function: ATP binding; calcium ion binding; calcium-transporting ATPase activity; hydrolase activity; metal ion binding; nucleotide binding; nucleotide-sugar transmembrane transporter activity; protein binding; protein homodimerization activity
Biological Process: apoptotic mitochondrial changes; calcium ion transport; cellular calcium ion homeostasis; elevation of endoplasmic reticulum calcium ion concentration; elevation of mitochondrial calcium ion concentration; ion transport; maintenance of mitochondrion localization; negative regulation of striated muscle contraction; positive regulation of fast-twitch skeletal muscle contraction; reduction of endoplasmic reticulum calcium ion concentration; regulation of muscle contraction; regulation of striated muscle contraction; response to peptide hormone stimulus; transport
Research Articles on Atp2a1
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Product Notes
The Mouse Atp2a1 atp2a1 (Catalog #AAA2884476) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2884476 ELISA Kit recognizes Mouse Atp2a1. It is sometimes possible for the material contained within the vial of "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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