Typical Testing Data/Standard Curve (for reference only)
Human Nodal homolog ELISA Kit | NODAL elisa kit
Human Nodal homolog ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]
Uniprot Description
NODAL: Essential for mesoderm formation and axial patterning during embryonic development. Defects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia. Belongs to the TGF-beta family.
Protein type: Motility/polarity/chemotaxis; Cytokine; Secreted; Secreted, signal peptide; Cell development/differentiation
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: extracellular space
Molecular Function: cytokine activity; growth factor activity; morphogen activity; receptor agonist activity; transforming growth factor beta receptor binding
Biological Process: axial mesodermal cell fate specification; BMP signaling pathway; brain development; cell development; cell migration involved in gastrulation; digestive tract morphogenesis; embryonic cranial skeleton morphogenesis; embryonic pattern specification; embryonic placenta development; embryonic process involved in female pregnancy; floor plate morphogenesis; formation of anatomical boundary; heart looping; liver development; maternal placenta development; maternal process involved in parturition; mesendoderm development; negative regulation of transcription from RNA polymerase II promoter; neural fold formation; placenta development; polarity specification of proximal/distal axis; positive regulation of activin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of gastrulation; repression of premature neural plate formation; stem cell maintenance; trophectodermal cellular morphogenesis; vasculature development
Disease: Heterotaxy, Visceral, 5, Autosomal
Research Articles on NODAL
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Product Notes
The Human NODAL nodal (Catalog #AAA2881269) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2881269 ELISA Kit recognizes Human NODAL. It is sometimes possible for the material contained within the vial of "Nodal homolog, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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