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Immununohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human tonsil using S100A4 Polycloanl Antibody at dilution of 1:200)

Rabbit anti-Human, Rat S100A4 Polyclonal Antibody | anti-S100A4 antibody

S100A4 Polyclonal Antibody

Gene Names
S100A4; 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98
Reactivity
Human, Rat
Applications
Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
S100A4; Polyclonal Antibody; S100A4 Polyclonal Antibody; 18A2; 42A; calcium Placental protein; Calvasculin; CAPL; Fibroblast specific protein 1; FSP1; Leukemia multidrug resistance associated protein; Malignant transformation suppression 1; Metastasin; MTS1; OTTHUMP00000015467; OTTHUMP00000015468; P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; Protein S100 A4; S100 calcium binding protein A4; S100a4; anti-S100A4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Form/Format
PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Concentration
1mg/mL (varies by lot)
Applicable Applications for anti-S100A4 antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:100-1:400
Immunogen
Recombinant Human Protein S100-A4 protein
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.

Immununohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human tonsil using S100A4 Polycloanl Antibody at dilution of 1:200)

Immununohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human tonsil using S100A4 Polycloanl Antibody at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lung using S100A4 Polycloanl Antibody at dilution of 1:200)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human lung using S100A4 Polycloanl Antibody at dilution of 1:200)

Immunohistochemsitry (IHC)]

(Immunohistochemistry of paraffin-embedded Human duodenal carcinoma using S100A4 Polycloanl Antibody at dilution of 1:200)

Immunohistochemsitry (IHC)] (Immunohistochemistry of paraffin-embedded Human duodenal carcinoma using S100A4 Polycloanl Antibody at dilution of 1:200)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Rat lung using S100A4 Polycloanl Antibody at dilution of 1:200)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Rat lung using S100A4 Polycloanl Antibody at dilution of 1:200)
Related Product Information for anti-S100A4 antibody
S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.
Product Categories/Family for anti-S100A4 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
101
NCBI Official Full Name
Protein S100-A4
NCBI Official Synonym Full Names
S100 calcium binding protein A4
NCBI Official Symbol
S100A4
NCBI Official Synonym Symbols
42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98
NCBI Protein Information
protein S100-A4; protein Mts1; fibroblast-specific protein-1; placental calcium-binding protein; malignant transformation suppression 1; leukemia multidrug resistance associated protein; S100 calcium-binding protein A4 (calcium protein, calvasculin, metas
UniProt Protein Name
Protein S100-A4
Protein Family
UniProt Gene Name
S100A4
UniProt Synonym Gene Names
CAPL; MTS1
UniProt Entry Name
S10A4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

S100A4: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; neuron projection; perinuclear region of cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; RAGE receptor binding; calcium ion binding; actin binding; calcium-dependent protein binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; epithelial to mesenchymal transition

Research Articles on S100A4

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Product Notes

The S100A4 s100a4 (Catalog #AAA2568141) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The S100A4 Polyclonal Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's S100A4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:100-1:400. Researchers should empirically determine the suitability of the S100A4 s100a4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "S100A4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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