Mouse anti-Human S100A4 Monoclonal Antibody | anti-S100A4 antibody

S100A4 Monoclonal Antibody

Cat. Num. AAA2563637

• Reactivity: Human
• Applications: Immunohistochemistry, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: S100A4; Monoclonal Antibody; S100A4 Monoclonal Antibody; 18A2; 42A; calcium Placental protein; Calvasculin; CAPL; Fibroblast specific protein 1 (FSP1); Fibroblast specific protein 1; Fibroblast specific protein; FSP1; Leukemia multidrug resistance associated protein; Malignant transformation suppression 1 (MTS1); Malignant transformation suppression 1; Metastasin; MTS1; OTTHUMP00000015467; OTTHUMP00000015468; P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; Protein S100 A4; Protein S100-A4; S100 calcium binding protein A4 (calcium protein; calvasculin; metastasin; murine placental homolog); S100 calcium binding protein A4; S100 calcium-binding protein A4; S100a4; S10A4; anti-S100A4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: LE2B2
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 101

• Applicable Applications for anti-S100A4 antibody: Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:200
• Immunogen: Full length protein from eukaryotic expression system.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20?. Avoid freeze/ thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human tonsil tissue using S100A4 Monoclonal Antibody dilution of 1:200.)

Related Product Information for anti-S100A4 antibody

S100A4 has been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis, and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo . It is a specific prognostic marker for renal survival in patients with IgAN . It is also an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.

Product Categories/Family for anti-S100A4 antibody

Cancer, Cardiovascular, Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 115601
• UniProt Accession #: P26447
• NCBI Official Full Name: Protein S100-A4
• UniProt Protein Name: Protein S100-A4
• Protein Family: Protein
• UniProt Gene Name: S100A4
• UniProt Synonym Gene Names: CAPL; MTS1
• UniProt Entry Name: S10A4_HUMAN

Uniprot Description

S100A4: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; neuron projection; perinuclear region of cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; RAGE receptor binding; calcium ion binding; actin binding; calcium-dependent protein binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; epithelial to mesenchymal transition