Western Blot (WB)
(Western blot analysis of extracts of various cell lines using SEC61B Polyclonal Antibody at dilution of 1:1000.)
Rabbit SEC61B Polyclonal Antibody | anti-SEC61B antibody
(KO Validated) SEC61B Polyclonal Antibody
IF: 1:50-1:200
Western Blot (WB)
(Western blot analysis of extracts of various cell lines using SEC61B Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines using SEC61B Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western blot analysis of extracts from normal (control) and SEC61B knockout (KO) 293T cells using SEC61B Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western blot analysis of extracts from normal (control) and SEC61B knockout (KO) 293T cells using SEC61B Polyclonal Antibody at dilution of 1:1000.)
Immunofluorescence (IF)
(Immunofluorescence analysis of L929 cells using SEC61B Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of L929 cells using SEC61B Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)
NCBI and Uniprot Product Information
NCBI Description
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
Uniprot Description
SEC61B: Necessary for protein translocation in the endoplasmic reticulum. Belongs to the SEC61-beta family.
Protein type: Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q22.33
Cellular Component: membrane; endoplasmic reticulum; integral to membrane
Molecular Function: protein binding; epidermal growth factor binding
Biological Process: retrograde protein transport, ER to cytosol; SRP-dependent cotranslational protein targeting to membrane; antigen processing and presentation of peptide antigen via MHC class I; ER-associated protein catabolic process; cellular protein metabolic process; translation; protein import into nucleus, translocation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression
Research Articles on SEC61B
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Product Notes
The SEC61B sec61b (Catalog #AAA2565409) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The (KO Validated) SEC61B Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SEC61B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:500-1:2000 IF: 1:50-1:200. Researchers should empirically determine the suitability of the SEC61B sec61b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEC61B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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