PSGL-1/CD162/SELPLG Recombinant Protein | Selplg recombinant protein

Recombinant Mouse PSGL-1/CD162/SELPLG Protein (C-Fc)

Cat. Num. AAA2557448

• Gene Names: Selplg; CD162; Psgl1; Selp1; Selpl; Psgl-1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: PSGL-1/CD162/SELPLG; Recombinant Mouse PSGL-1/CD162/SELPLG Protein (C-Fc); CLA; CD162; PSGL1; PSGL-1; Selplg recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH7.4.
• Sequence: Gln42-Cys307
• Sequence Length: 397

• Species: Mouse
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for Selplg recombinant protein

Protein Construction: Recombinant Mouse PSGL-1 is produced by our mammalian expression system and the target gene encoding Gln42-Cys307 is expressed with a Fc tag at the C-terminus.

Background: P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin.

NCBI and Uniprot Product Information

• NCBI GI #: 341942014
• NCBI GeneID: 20345
• UniProt Accession #: Q62170
• Molecular Weight: Molecular Mass: 54.7kDa; Actual Protein Molecular Mass: 90kDa
• NCBI Official Full Name: P-selectin glycoprotein ligand 1
• NCBI Official Synonym Full Names: selectin, platelet (p-selectin) ligand
• NCBI Official Symbol: Selplg
• NCBI Official Synonym Symbols: CD162; Psgl1; Selp1; Selpl; Psgl-1
• NCBI Protein Information: P-selectin glycoprotein ligand 1
• UniProt Protein Name: P-selectin glycoprotein ligand 1
• Protein Family: P-selectin glycoprotein ligand
• UniProt Gene Name: Selplg
• UniProt Synonym Gene Names: Selp1; Selpl; PSGL-1

Uniprot Description

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.