Neuroblastoma Suppressor of Tumorigenicity 1/NBL1 Recombinant Protein | NBL1 recombinant protein
Recombinant Mouse Neuroblastoma Suppressor of Tumorigenicity 1/NBL1 Protein (C-6His)
Gene Names
Nbl1; DAN; NO3; Dana; D4H1S1733E
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Neuroblastoma Suppressor of Tumorigenicity 1/NBL1; Recombinant Mouse Neuroblastoma Suppressor of Tumorigenicity 1/NBL1 Protein (C-6His); DAND1; NBL1; DAN domain family member 1; neuroblastoma suppressor of tumorigenicity 1; Protein N03; suppression of tumorigenicity 1; NBL1 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
Sequence Positions
Ala17-Asp178
Sequence Length
178
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fusion Tag
C-6His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for NBL1 recombinant protein
Differential screening-selected gene aberrative in neuroblastoma (DAN) is a member of the DAN family of secreted glycoproteins. DAN family antagonists are characterized by a DAN domain that contains a cystine knot motif which is essential for binding to BMP ligands. Members of this family include DAN, gremlin, protein related to DAN and cerberus (PRDC), cerberus, sclerostin (SOST) and uterine sensitization-associated gene 1 protein, and control diverse processes in growth, development and the cell cycle. It has also been reported that DAN family plays crucial role in early mouse embryo development by inhibiting the action of bone morphogenic proteins and modulating the action of transforming growth factor-beta superfamily members. DAN is synthesized by small-to intermediate-sized DRG neurons and transported to the sensory nerve terminals in the skin or to the sensory nerve terminals in the dorsal horn. It has been reported that DAN is ubiquitously expressed in adult rat and human tissues. Morphological studies have revealed that, in adult rat, DAN mRNA is expressed ubiquitously in lung and brain, but not in liver.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 18.4 kDa
Actual Protein Molecular Mass: 25-28 kDa
Actual Protein Molecular Mass: 25-28 kDa
NCBI Official Full Name
neuroblastoma suppressor of tumorigenicity 1
NCBI Official Synonym Full Names
neuroblastoma, suppression of tumorigenicity 1
NCBI Official Symbol
Nbl1
NCBI Official Synonym Symbols
DAN; NO3; Dana; D4H1S1733E
NCBI Protein Information
neuroblastoma suppressor of tumorigenicity 1
UniProt Protein Name
Neuroblastoma suppressor of tumorigenicity 1
Protein Family
UniProt Gene Name
Nbl1
UniProt Synonym Gene Names
Dan; Dana
Uniprot Description
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Research Articles on NBL1
1. DAN is a novel autocrine/paracrine factor that modulates GnRH function in pituitary gonadotropes.
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Product Notes
The NBL1 nbl1 (Catalog #AAA2553585) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Ala17-Asp178. It is sometimes possible for the material contained within the vial of "Neuroblastoma Suppressor of Tumorigenicity 1/NBL1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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