Xaa-Pro Aminopeptidase 1/XPNPEP1 Recombinant Protein | XPNPEP1 recombinant protein

Recombinant Human Xaa-Pro Aminopeptidase 1/XPNPEP1 Protein (C-6His)

Cat. Num. AAA2553388

• Gene Names: XPNPEP1; APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Xaa-Pro Aminopeptidase 1/XPNPEP1; Recombinant Human Xaa-Pro Aminopeptidase 1/XPNPEP1 Protein (C-6His); Xaa-Pro Aminopeptidase 1; Aminoacylproline Aminopeptidase; Cytosolic Aminopeptidase P; Soluble Aminopeptidase P; sAmp; X-Pro Aminopeptidase 1; X-Prolyl Aminopeptidase 1 Soluble; XPNPEP1; XPNPEPL; XPNPEPL1; XPNPEP1 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM Tris HCl, 10% Glycerol, pH 8.0.
• Sequence Positions: Pro2-His623
• Sequence Length: 642

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for XPNPEP1 recombinant protein

X-Prolyl Aminopeptidase (XPNPEP1) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-Prolyl Aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby complementing the pancreatic peptidases. X-Prolyl Aminopeptidase is a member of the M24 family of metalloproteases, which also contains methionine aminopeptidases, X-Pro dipeptidase, aminopeptidase P2, aminopeptidase P homolog, proliferation-associated protein 1, and suppressor of Ty homolog or chromatin-specific transcription elongation factor large subunit. It is a soluble enzyme, in contrast to the GPI-anchored Aminopeptidase P2 encoded by XPNPEP2. Deficiency of X-Prolyl Aminopeptidase results in excretion of large amounts of imino-oligopeptides in urine. Human Aminopeptidase P1 is widely expressed. The amino acid sequence of human X-Prolyl Aminopeptidase is 99%, 97%, 95%, 74% and 73% identical to that of canine, bovine, mouse/rat, Xenopus and zebrafish, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 264681565
• NCBI GeneID: 7511
• NCBI Accession #: NP_001161076.1
• NCBI GenBank Nucleotide #: NM_001167604.1
• UniProt Accession #: Q9NQW7; O15250; Q53EX6; Q8N3Q0; Q96D23; A8K071; G5E9Y2; G8JLB2
• Molecular Weight: Molecular Mass: 70.6 kDa; Actual Protein Molecular Mass: 77 kDa
• NCBI Official Full Name: xaa-Pro aminopeptidase 1 isoform 2
• NCBI Official Synonym Full Names: X-prolyl aminopeptidase 1
• NCBI Official Symbol: XPNPEP1
• NCBI Official Synonym Symbols: APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1
• NCBI Protein Information: xaa-Pro aminopeptidase 1
• UniProt Protein Name: Xaa-Pro aminopeptidase 1
• UniProt Gene Name: XPNPEP1
• UniProt Synonym Gene Names: sAmp

NCBI Description

This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

Uniprot Description

Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.