NKG2D Ligand 2/NKG2DL2/N2DL2 Recombinant Protein | NKG2DL2/N2DL2 recombinant protein
Recombinant Human NKG2D Ligand 2/NKG2DL2/N2DL2 Protein (C-6His)
Gene Names
ULBP2; N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha
Purity
>90% as determined by reducing SDS-PAGE.
Synonyms
NKG2D Ligand 2/NKG2DL2/N2DL2; Recombinant Human NKG2D Ligand 2/NKG2DL2/N2DL2 Protein (C-6His); NKG2D Ligand 2; N2DL-2; NKG2DL2; ALCAN-Alpha; Retinoic Acid Early Transcript 1H; UL16-Binding Protein 2; ULBP2; N2DL2; RAET1H; NKG2DL2/N2DL2 recombinant protein
Host
Human Cells
Purity/Purification
>90% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Sequence Positions
Gly26-Ser217
Sequence Length
246
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fusion Tag
C-6His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for NKG2DL2/N2DL2 recombinant protein
NKG2D Ligand 2 (N2DL2) is a member of a family of cell-surface proteins. N2DL2 function as ligands for human cytomegalovirus glycoprotein UL16. N2DL2 is anchored to the membrane via a GPI-linkage. N2DL2 is bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells. Engagement of NKG2D results in the activation of cytolytic activity and cytokine production by these effects cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 22.8 kDa
Actual Protein Molecular Mass: 30 kDa
Actual Protein Molecular Mass: 30 kDa
NCBI Official Full Name
UL16-binding protein 2 preproprotein
NCBI Official Synonym Full Names
UL16 binding protein 2
NCBI Official Symbol
ULBP2
NCBI Official Synonym Symbols
N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha
NCBI Protein Information
UL16-binding protein 2
UniProt Protein Name
UL16-binding protein 2
UniProt Gene Name
ULBP2
UniProt Synonym Gene Names
N2DL2; RAET1H; N2DL-2; NKG2DL2
NCBI Description
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
Uniprot Description
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Research Articles on NKG2DL2/N2DL2
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Product Notes
The NKG2DL2/N2DL2 ulbp2 (Catalog #AAA2553018) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Gly26-Ser217. It is sometimes possible for the material contained within the vial of "NKG2D Ligand 2/NKG2DL2/N2DL2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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