CL-K1 / COLEC11 recombinant protein

Recombinant Mouse CL-K1 / COLEC11 Protein (His tag)

Cat. Num. AAA2547107

• Gene Names: Colec11; CL-K1
• Purity: > 95 % as determined by SDS-PAGE
• Synonyms: CL-K1 / COLEC11; Recombinant Mouse CL-K1 / COLEC11 Protein (His tag); COLEC11; CL-K1 / COLEC11 recombinant protein

• Host: Baculovirus-Insect Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.4
• Sequence Length: 272

• Application Notes: The recombinant mouse COLEC11 comprises 256 amino acids and has a predicted molecular mass of 27.6 kDa. The apparent molecular mass of the protein is approximately 33-37 kDa in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Gln 27
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CL-K1 / COLEC11 recombinant protein

A DNA sequence encoding the mouse COLEC11 (Q3SXB8-1) (Met1-Leu272) was expressed with a C-terminal polyhistidine tag.

NCBI and Uniprot Product Information

• NCBI GI #: 103472134
• NCBI GeneID: 71693
• NCBI Accession #: NP_082142.1
• NCBI GenBank Nucleotide #: NM_027866.2
• UniProt Accession #: Q3SXB8; Q3SXB7; Q9DC75
• Molecular Weight: 29,526 Da
• NCBI Official Full Name: collectin-11 isoform 2
• NCBI Official Synonym Full Names: collectin sub-family member 11
• NCBI Official Symbol: Colec11
• NCBI Official Synonym Symbols: CL-K1
• NCBI Protein Information: collectin-11
• UniProt Protein Name: Collectin-11
• UniProt Gene Name: Colec11
• UniProt Synonym Gene Names: CL-K1

NCBI Description

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in the human gene are a cause of 3MC syndrome-2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Uniprot Description

COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12|12 A2