COLEC11 recombinant protein

COLEC11 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122607

• Gene Names: Colec11; 1010001H16Rik
• Purity: >95% as determined by SDS-PAGE
• Synonyms: COLEC11; COLEC11 Protein; Mouse; Recombinant (His Tag); Mouse CL-K1/COLEC11 Protein (His Tag); 1010001H16Rik Protein; collectin sub-family member 11; COLEC11 recombinant protein

• Host: Baculovirus-Insect Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Leu272

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 27
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse COLEC11 (Q3SXB8-1)(Met1-Leu272) was expressed with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 103472134
• NCBI GeneID: 71693
• NCBI Accession #: NP_082142.1
• NCBI GenBank Nucleotide #: NM_027866.1
• UniProt Accession #: Q3SXB8; Q3SXB7; Q9DC75
• Molecular Weight: 28,989 Da
• NCBI Official Full Name: collectin-11
• NCBI Official Synonym Full Names: collectin sub-family member 11
• NCBI Official Symbol: Colec11
• NCBI Official Synonym Symbols: 1010001H16Rik
• NCBI Protein Information: collectin-11; CL-K1; collectin kidney protein 1
• UniProt Protein Name: Collectin-11
• Protein Family: Collectin
• UniProt Gene Name: Colec11
• UniProt Synonym Gene Names: CL-K1
• UniProt Entry Name: COL11_MOUSE

Uniprot Description

COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: collagen; extracellular region

Molecular Function: mannose binding; carbohydrate binding

Biological Process: multicellular organismal development