SDS-PAGE
FOLR1 / FR-alpha recombinant protein
Recombinant Mouse FOLR1 / FR-alpha Protein (His tag)
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
Uniprot Description
FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 7|7 E2
Cellular Component: anchored to external side of plasma membrane; anchored to plasma membrane; apical plasma membrane; basolateral plasma membrane; brush border; brush border membrane; cell surface; membrane; nucleus
Molecular Function: drug binding; folic acid binding; folic acid transporter activity; methotrexate binding; receptor activity
Biological Process: axon regeneration; folic acid metabolic process; folic acid transport; heart looping; posttranslational protein targeting to membrane; regulation of transforming growth factor beta receptor signaling pathway; response to axon injury
Research Articles on FOLR1 / FR-alpha
Similar Products
Product Notes
The FOLR1 / FR-alpha folr1 (Catalog #AAA2546907) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse FOLR1 consists of 218 amino acids and has a predicted molecular mass of 25.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmFOLR1 is approximately 33-37 kDa due to glycosylation. Researchers should empirically determine the suitability of the FOLR1 / FR-alpha folr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOLR1 / FR-alpha, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
