Rabbit anti-Rat FCAR  Monoclonal Antibody | anti-FCAR  antibody

Rabbit anti Rat FCAR  Monoclonal Antibody

Cat. Num. AAA2544692

• Gene Names: FCAR; CD89; FcalphaRI; CTB-61M7.2
• Reactivity: Rat
• Applications: ELISA
• Synonyms: FCAR ; Monoclonal Antibody; Rabbit anti Rat FCAR Monoclonal Antibody; anti-FCAR antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 96

• Applicable Applications for anti-FCAR antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Rat CD89/FCAR. The detection limit for Rat CD89/FCAR is approximately 0.0195 ng/well.
• Immunogen: Recombinant Rat CD89/FCAR protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-FCAR  antibody

FCAR, also called FcalphaRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcalphaRI associates with the FcR gamma signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcalphaRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcalphaRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

NCBI and Uniprot Product Information

• NCBI GI #: 129447255
• NCBI GeneID: 2204
• Molecular Weight: 28,343 Da
• NCBI Official Full Name: FCAR, partial
• NCBI Official Synonym Full Names: Fc fragment of IgA receptor
• NCBI Official Symbol: FCAR
• NCBI Official Synonym Symbols: CD89; FcalphaRI; CTB-61M7.2
• NCBI Protein Information: immunoglobulin alpha Fc receptor
• UniProt Protein Name: Immunoglobulin alpha Fc receptor
• UniProt Gene Name: FCAR
• UniProt Synonym Gene Names: CD89; IgA Fc receptor
• UniProt Entry Name: FCAR_HUMAN

NCBI Description

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FCAR: Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: immune response