Rabbit anti-Mouse SCGB1A1  Monoclonal Antibody | anti-SCGB1A1  antibody

Rabbit anti Mouse SCGB1A1  Monoclonal Antibody

Cat. Num. AAA2544539

• Gene Names: SCGB1A1; UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: SCGB1A1 ; Monoclonal Antibody; Rabbit anti Mouse SCGB1A1 Monoclonal Antibody; anti-SCGB1A1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 91

• Applicable Applications for anti-SCGB1A1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse SCGB1A1. The detection limit for Mouse SCGB1A1 is approximately 0.00245 ng/well.
• Immunogen: Recombinant Mouse Uteroglobin/SCGB1A1 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SCGB1A1  antibody

Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A (2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 49456517
• NCBI GeneID: 7356
• UniProt Accession #: P11684; Q6FHH3; Q9UCM2; Q9UCM4; B2R5F2
• Molecular Weight: 9,994 Da
• NCBI Official Full Name: SCGB1A1, partial
• NCBI Official Synonym Full Names: secretoglobin family 1A member 1
• NCBI Official Symbol: SCGB1A1
• NCBI Official Synonym Symbols: UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
• NCBI Protein Information: uteroglobin
• UniProt Protein Name: Uteroglobin
• UniProt Gene Name: SCGB1A1
• UniProt Synonym Gene Names: CC10; CCSP; UGB; CCPBP; CC10; UP-1; UP1; Urine protein 1
• UniProt Entry Name: UTER_HUMAN

NCBI Description

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

Uniprot Description

SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.

Protein type: Cell cycle regulation; Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q12.3

Molecular Function: protein binding

Biological Process: embryo implantation

Disease: Asthma, Susceptibility To