Rabbit anti-Human GFRA3 Monoclonal Antibody | anti-GFRA3 antibody
Rabbit anti Human GFRA3 Monoclonal Antibody
Gene Names
GFRA3; GDNFR3
Reactivity
Human
Applications
ELISA
Purity
Affinity Purification
Synonyms
GFRA3 ; Monoclonal Antibody; Rabbit anti Human GFRA3 Monoclonal Antibody; Anti-GDNFR3 Antibody; anti-GFRA3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Purity/Purification
Affinity Purification
Form/Format
0.2 um filtered solution in PBS
Sequence Length
400
Applicable Applications for anti-GFRA3 antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10000
Immunogen
Recombinant Human GFRA3 protein
Buffer
This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA3 (rh GFRA3; NP_001487.2; Met 1-Trp 382).
Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Store at 20°C. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-GFRA3 antibody
Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNFreceptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor ?3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
GDNF family receptor alpha-3 preproprotein
NCBI Official Synonym Full Names
GDNF family receptor alpha 3
NCBI Official Symbol
GFRA3
NCBI Official Synonym Symbols
GDNFR3
NCBI Protein Information
GDNF family receptor alpha-3
UniProt Protein Name
GDNF family receptor alpha-3
UniProt Gene Name
GFRA3
UniProt Synonym Gene Names
GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3
UniProt Entry Name
GFRA3_HUMAN
NCBI Description
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]
Uniprot Description
GFRA3: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 5q31.1-q31.3
Cellular Component: cytoplasm; extrinsic to membrane; intracellular membrane-bound organelle; plasma membrane
Molecular Function: Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: MAPKKK cascade; nervous system development; peripheral nervous system development; signal transduction
